Combination of 15 lipid metabolites and motilin to diagnose spleen-deficiency FD
Combination of 15 lipid metabolites and motilin to diagnose spleen-deficiency FD
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15种脂质代谢物与胃动素联合诊断脾虚FD
DOI：
10.1186/s13020-019-0238-9
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发表时间：
2019-04-15
期刊：
影响因子：
4.9
通讯作者：
Tang，Xudong
中科院分区：
文献类型：
--
作者：
Zhang，Jiaqi;Wang，Xue;Tang，Xudong
背景本研究旨在探讨FD脾虚证的临床特点及代谢紊乱在FD进展中的作用。我们结合代谢生物标志物和临床特征到一个更好的预测FD与脾虚证。方法共招募了276人，其中包括215 FD患者和61健康对照组（HC）。比较脾虚型FD与非脾虚型FD的临床特征及胃排空率。结果与非脾虚组比较，脾虚FD组餐后不适症状明显加重（P <0. 05），胃排空障碍明显加重（P <0. 05）。胃动素降低（OR = 0.990，95%可信区间（CI）0.982-0.997）是脾虚证的独立危险因素。我们鉴定了脾虚组与HC组的15种代谢物，这些生物标志物大多属于甘油磷脂代谢途径。15种代谢物联合检测可诊断脾虚型FD，AUC为0.9943，95% CI为0.9854-1.0000; 15种代谢物联合检测与胃动素联合检测可诊断脾虚型FD，AUC为0.9615，结论FD患者脾虚证与胃排空延迟及甘油磷脂代谢途径紊乱有关。代谢生物标志物与临床特征的结合为FD的多维诊断提供了新的思路。试验注册http：www.chictr.org.cn ，编号：ChiCTR-TRC-13003200。clinicaltrials.gov，编号：NCT 02762136
BackgroundThis study aims to assess clinical characteristics in FD with spleen deficiency syndrome and metabolic perturbations involved in FD progress. We combined metabolic biomarkers and clinical features into a better prediction for FD with Spleen Deficiency syndrome.MethodsA total of 276 people were recruited, including 215 FD patients and 61 healthy control group (HC). The clinical characteristics and gastric emptying rate were compared between spleen deficiency-FD group and non-spleen deficiency-FD. The serum lipids metabonomics analysis was performed to determine the metabolic differences in spleen deficiency-FD group and HC.ResultsThe symptoms of postprandial discomfort in Spleen Deficiency group were more severe (P < 0.05), and delayed gastric emptying was more pronounced (P < 0.05) vs. non-Spleen deficiency. Decreased motilin (OR = 0.990, 95% confidence interval (CI) 0.982–0.997) was independent risk factor related to Spleen Deficiency group. We identified 15 metabolites for spleen deficiency group vs. HC, majority of those biomarkers belonged to the glycerophospholipid metabolic pathway. The combination of 15 metabolics could diagnose spleen deficiency-FD, with the AUC of 0.9943, 95% CI 0.9854–1.0000), and the combination of 15 metabolics and motilin could diagnose spleen deficiency-FD, with the AUC of 0.9615, 95% CI 0.9264–9967).ConclusionsThis study provides supportive evidence that Spleen deficiency syndrome was associated with delayed gastric emptying and the glycerophospholipid metabolic pathway was perturbed in FD patients. The combination of metabolic biomarkers and clinical features provided us with new ideas for multidimensional diagnosis of FD.Trial registrationhttp://www.chictr.org.cn , no: ChiCTR-TRC-13003200. clinicaltrials.gov, no: NCT02762136