Minimal residual disease after allogeneic bone marrow transplantation for chronic myeloid leukaemia in first chronic phase: correlations with acute graft‐versus‐host disease and relapse
Minimal residual disease after allogeneic bone marrow transplantation for chronic myeloid leukaemia in first chronic phase: correlations with acute graft‐versus‐host disease and relapse
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慢性粒细胞白血病第一慢性期同种异体骨髓移植后的微小残留病：与急性移植物抗宿主病和复发的相关性
DOI：
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发表时间：
1993
影响因子：
6.5
通讯作者：
J. Goldman
中科院分区：
文献类型：
--
作者：
N. Cross;T. Hughes;Lin Feng;P. O'Shea;J. Bungey;D. Marks;A. Ferrant;P. Martiat;J. Goldman
Summary. We have studied 61 patients who underwent allogeneic bone marrow transplantation (BMT) for chronic myeloid leukaemia (CML) in first chronic phase. Minimal residual disease was detected by the amplification of the leukaemia‐specific BCR‐ABL fusion mRNA with the polymerase chain reaction (PCR) using a highly sensitive nested primer strategy. As a general pattern, patients often had detectable BCR‐ABL (PCR positive) for up to 6 or 9 months post BMT after which time BCR‐ABL became undetectable (PCR negative). The conversion from PCR positive to PCR negative was not associated with the time at which cyclosporin A treatment was stopped. Six patients (10%) have relapsed during the period of this study, two within 1 year and four more than 1 year after transplant. The relationship between PCR positivity more than 1 year post transplant and relapse was significant (P= 0·036) but 15 patients who were PCR positive beyond 1 year remain in complete clinical and cytogenetic remission. Thus late positivity identifies a group of patients at increased risk of relapse but is of little predictive value for individual patients. Of the four late relapses, two had been persistently PCR positive and two were initially PCR positive, converted to negative and subsequently to positive again. Although all relapses were preceded by PCR positivity, relapse may occur only 12 months after a PCR negative result. The proportion of patients PCR negative at 3/4 months after BMT was found to increase significantly with the severity of acute GVHD (P= 0·002) but no relationship was found between acute GVHD and subsequent PCR results. There was no clear association between severity of chronic GVHD and PCR result.
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聚合酶链反应检测慢性粒细胞白血病同种异体骨髓移植后bcr-abl基因重排的临床意义
影响因子：
20.3
作者：
Delage,R;Soiffer,RJ;Dear,K;Ritz,J
通讯作者：
Ritz,J
骨髓移植后慢性粒细胞白血病残留疾病的分子定量。
影响因子：
20.3
作者：
Thompson,JD;Brodsky,I;Yunis,JJ
通讯作者：
Yunis,JJ
影响因子：
20.3
作者：
M. Horowitz;R. Gale;P. Sondel;J. Goldman;J. Kersey;H. Kolb;A. Rimm;O. Ringdén;C. Rozman
通讯作者：
M. Horowitz;R. Gale;P. Sondel;J. Goldman;J. Kersey;H. Kolb;A. Rimm;O. Ringdén;C. Rozman
影响因子：
39.2
作者：
THOMAS, ED;CLIFT, RA;WITHERSPOON, R
通讯作者：
WITHERSPOON, R
影响因子：
39.2
作者：
GOLDMAN, JM;GALE, RP;BORTIN, MM
通讯作者：
BORTIN, MM