Time-dependent quantifiable withdrawal from ethanol in the rat: Effect of method of dependence induction
Time-dependent quantifiable withdrawal from ethanol in the rat: Effect of method of dependence induction
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DOI：
10.1016/0741-8329(95)02030-6
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发表时间：
1996-03-01
期刊：
影响因子：
2.3
通讯作者：
Koob, GF
中科院分区：
文献类型：
--
作者：
Macey, DJ;Schulteis, G;Koob, GF
使用分级量表、震颤和声学惊吓范例来量化时间因素对大鼠酒精戒断症状的存在和严重程度的重要性。给幼龄雄性Wistar大鼠灌胃液体饮食(n=21)或雾化吸入酒精(n=13)，建立酒精依赖模型。在戒酒72小时后进行的重复测量试验中，受试者对生理性酒精依赖的强度和持续时间进行了分析。依赖的指标包括中枢神经系统过度兴奋，表现为可见的戒断迹象，声学惊厥反应增加，以及震颤活动。数据分析显示，观察到的和诱发的戒断体征一般在戒断后12-24小时达到峰值，并且蒸气吸入比液体饮食更容易观察到，可能是因为吸入过程中获得了更高的BALS。结果表明，不同的行为范式观察到的时间进程是不同的。具体地说，对惊吓刺激的敏化可能与惊吓强度和依赖诱导方法无关。支配这些行为时程差异的神经底物仍有待确定。
The importance of temporal factors on the presence and severity of ethanol withdrawal signs in the rat was quantified using rating scale, tremor, and acoustic startle paradigms. Ethanol dependence was induced in naive male Wistar rats by liquid diet administration (n = 21) or vapor inhalation (n = 13). Subjects were analyzed for intensity and duration of physiological ethanol dependence in repeated-measures trials conducted over 72 h post-ethanol withdrawal. Indices of dependence included CNS hyperexcitability manifested as observable withdrawal signs increased acoustic startle reactivity, and tremor activity. Data analysis revealed that withdrawal signs, observed and elicited, generally reached peak intensities between 12 and 24 h postwithdrawal and were more readily observed following vapor inhalation than liquid diet administration, probably because of the higher BALs attained with the inhalation procedure. Results suggest a difference in time course observed with the different behavioral paradigms. In particular, a possible sensitization to startle stimuli was exhibited independent of both startle intensity and dependence induction method. The neural substrates governing these behavioral time course differences remain to be determined.