Variability of gray and white matter during normal development: a voxel-based MRI analysis
Variability of gray and white matter during normal development: a voxel-based MRI analysis
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DOI：
10.1097/00001756-200310270-00001
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发表时间：
2003-10-27
期刊：
影响因子：
1.7
通讯作者：
Holland, SK
中科院分区：
文献类型：
--
作者：
Wilke, M;Holland, SK
本研究旨在调查正常人脑发育过程中脑组织的区域和局部变异性。我们使用 SPM99（英国伦敦大学学院威康系）研究了高分辨率 MR 成像数据。计算灰质和白质的像素变异系数以可视化局部变异性。对 200 名正常儿童（5-18 岁）的数据进行了分析。我们发现大脑结构的变异性与灰质和白质的正常发育之间存在着深刻的相互作用。灰质和白质的变异显示出区域特定的、与年龄相关的变异，可能为评估微妙的大脑异常提供一种新工具。我们的结果强调了在规划儿科神经影像研究时考虑这种变异性的必要性。
This study was aimed at investigating regional and local variability of brain tissue during normal human brain development. We investigated high-resolution MR-imaging data using SPM99 (Wellcome Department, University College London, UK). A pixel-wise variation coefficient of gray and white matter was calculated to visualize local variability. Data from 200 normal children (5-18 years) were analyzed. We found a profound interaction between variability of brain structures and normal development in both gray and white matter. Variability in gray and white matter shows regionally specific, age-related variations, possibly offering a new tool for the assessment of subtle brain abnormalities. Our results emphasize the necessity to take this variability into account when planning pediatric neuroimaging studies.