Impaired vocal cord mobility in T2N0 glottic carcinoma: Suboptimal local control with Radiation alone
Impaired vocal cord mobility in T2N0 glottic carcinoma: Suboptimal local control with Radiation alone
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DOI：
10.1002/hed.24520
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发表时间：
2016-12-01
影响因子：
2.9
通讯作者：
Koyfman, Shlomo A.
中科院分区：
文献类型：
--
作者：
Bhateja, Priyanka;Ward, Matthew C.;Koyfman, Shlomo A.
背景。已知T2声门癌合并声带活动受损（T2b）与单纯放疗（RT）治疗的未受损声带活动的T2声门癌（T2a）相比有更高的局部失败率。在这项回顾性研究中，我们确定并比较了3组患者的局部控制率：T2aN0组接受RT治疗；T2bN0采用RT治疗；化疗（CRT）治疗T2b-3N0-2。T2aN0组3年局部控制率为95.1%，T2bN0组放疗组为73.2%，CRT组为91.5% （p = 0.01）。在单因素分析中，T2bN0疾病与单纯RT治疗T2aN0相比（p = 0.03）与较差的局部控制显著相关。声门癌合并声带活动能力受损（T2b）的患者单独RT有很高的局部失败率。对于希望保留喉部并愿意接受潜在毒性的患者，应考虑同时进行化疗。(C) 2016 Wiley期刊公司
Background. T2 glottic cancer with impaired vocal cord mobility (T2b) is known to have higher local failure rates when compared with T2 cancers without impaired cord mobility (T2a) treated with radiotherapy (RT) alone.Methods. In this retrospective review, we identified and compared the local control rates of 3 groups: T2aN0 treated with RT; T2bN0 treated with RT; and T2b-3N0-2 treated with chemoradiotherapy (CRT).Results. The 3-year local control rate was 95.1% for T2aN0, 73.2% for T2bN0 treated with RT, and 91.5% for the CRT group (p = .01). On univariate analysis, T2bN0 disease versus T2aN0 treated with RT alone (p = .03) was significantly associated with inferior local control.Conclusion. Patients with glottic cancer with impaired vocal cord mobility (T2b) have a high rate of local failure with RT alone. The addition of concurrent chemotherapy should be considered for patients highly motivated toward larynx preservation and willing to accept the potential toxicity. (C) 2016 Wiley Periodicals, Inc.