A new porous tracheal prosthesis sealed with collagen sponge.
A new porous tracheal prosthesis sealed with collagen sponge.
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一种用胶原海绵密封的新型多孔气管假体。
DOI：
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发表时间：
1995
期刊：
影响因子：
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通讯作者：
Y. Shimizu
中科院分区：
文献类型：
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作者：
M. Teramachi;T. Kiyotani;Y. Takimoto;T. Nakamura;Y. Shimizu
我们设计了一种新的气管假体，以克服早期设备的问题，包括狭窄和其组成网的暴露。聚丙烯网筒，用聚丙烯螺旋加固，用猪真皮胶原蛋白制成的胶原海绵密封。使用该假体，我们对11只狗进行了颈椎气管重建。3只狗在重建后3个月内死亡。死亡原因分别为麻醉意外、腹泻和窒息。经支气管镜检查，2个月时假体内表面几乎被宿主组织覆盖。然而，在一只狗中，在6个月时，相对大面积的网状物暴露在气管腔中；另外两只狗的暴露区域较小。即使在12个月后，内表面的外观迅速变得有光泽，中央狭窄也不明显。组织学上，6个月时重建表面可见不完整的上皮衬里，包括纤毛柱状上皮、立方状上皮和鳞状上皮。这些观察结果表明，这种假体具有很高的生物相容性和克服假体管腔狭窄问题的潜力。然而，由于这种假体持续存在溃疡，需要进一步改进以减少补片暴露的发生率。
We have designed a new tracheal prosthesis to overcome problems with an earlier device, which included stenosis and exposure of its constituent mesh. A polypropylene mesh cylinder, reinforced with a polypropylene spiral, is sealed with collagen sponge made from porcine dermal collagen. Using this prosthesis, we performed cervical tracheal reconstructions on 11 dogs. Three dogs died within 3 months of reconstruction. Their causes of death were anesthetic accident, diarrhea, and suffocation, respectively. Bronchoscopically, the inner surface of the prosthesis was almost covered with host tissue by 2 months. However, in one dog, a relatively large area of the mesh was exposed in the tracheal lumen at 6 months; a smaller area was exposed in two other dogs. The appearance of the inner surface rapidly became lustrous, and central stenosis was not significant, even after 12 months. Histologically, an incomplete epithelial lining at 6 months was seen on the reconstructed surface and included ciliated columnar, cuboidal, and squamous epithelium. These observations have revealed that this prosthesis has high biocompatibility and the potential to overcome problems of stenosis of the prosthesis lumen. However, because ulceration persists with this prosthesis, additional improvement is needed to reduce the incidence of mesh exposure.