Schistosomiasis research in the dongting lake region and its impact on local and national treatment and control in China.
Schistosomiasis research in the dongting lake region and its impact on local and national treatment and control in China.
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DOI：
10.1371/journal.pntd.0001053
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发表时间：
2011-08
影响因子：
3.8
通讯作者：
Li YS
中科院分区：
文献类型：
--
作者：
McManus DP;Gray DJ;Ross AG;Williams GM;He HB;Li YS
血吸虫病是一种慢性的、使人衰弱的寄生虫病，常常被忽视，因为它是一种贫困疾病，影响着发展中国家的贫困农村社区。但在中国，情况并非如此。在中国，这种由日本血吸虫引起的疾病长期以来一直受到中国当局的关注，在过去的50-60年里，中国当局实施了非常成功的控制计划，大大减轻了血吸虫病的疾病负担。湖南省洞庭湖区是我国血吸虫病的主要流行区之一，其广阔的沼泽地是日本钉螺中间宿主的栖息地。加上社会、人口和其他环境因素，最近三峡大坝的建成和关闭极有可能扩大这些钉螺栖息地的范围，血吸虫病再次出现的可能性和湖南等血吸虫病流行省份的传播增加是一个特别令人担忧的问题。本文回顾了洞庭湖区血吸虫病防治的历史和现状。我们探讨了导致日本血吸虫病传播的流行病学因素，并总结了过去10年湖南省血吸虫病研究的一些关键研究成果。强调了这项研究对当前和未来中国血吸虫病流行地区可持续综合控制方法的影响。
Schistosomiasis is a chronic and debilitating parasitic disease that has often been neglected because it is a disease of poverty, affecting poor rural communities in the developing world. This is not the case in the People's Republic of China (PRC), where the disease, caused by Schistosoma japonicum, has long captured the attention of the Chinese authorities who have, over the past 50–60 years, undertaken remarkably successful control programs that have substantially reduced the schistosomiasis disease burden. The Dongting Lake region in Hunan province is one of the major schistosome-endemic areas in the PRC due to its vast marshland habitats for the Oncomelania snail intermediate hosts of S. japonicum. Along with social, demographic, and other environmental factors, the recent completion and closure of the Three Gorges dam will most likely increase the range of these snail habitats, with the potential for re-emergence of schistosomiasis and increased transmission in Hunan and other schistosome-endemic provinces being a particular concern. In this paper, we review the history and the current status of schistosomiasis control in the Dongting Lake region. We explore the epidemiological factors contributing to S. japonicum transmission there, and summarise some of the key research findings from studies undertaken on schistosomiasis in Hunan province over the past 10 years. The impact of this research on current and future approaches for sustainable integrated control of schistosomiasis in this and other endemic areas in the PRC is emphasised.
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DOI：
10.2471/blt.08.053041
发表时间：
2008-10-01
期刊：
Bulletin of the World Health Organization: International Journal of Public Health
影响因子：
--
作者：
Hou, Xun-Ya;McManus, Donald P;Li, Yue-Sheng
通讯作者：
Li, Yue-Sheng
影响因子：
2.7
作者：
Li, YS;Kardorff, R;Hatz, C
通讯作者：
Hatz, C
影响因子：
3.9
作者：
Chen, ZY;Li, JF;Wang, ZH
通讯作者：
Wang, ZH
影响因子：
56.3
作者：
Gray, Darren J.;McManus, Donald P.;Ross, Allen G.
通讯作者：
Ross, Allen G.
DOI：
10.1084/jem.20090383
发表时间：
2009-10-26
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Dessein A;Chevillard C;Arnaud V;Hou X;Hamdoun AA;Dessein H;He H;Abdelmaboud SA;Luo X;Li J;Varoquaux A;Mergani A;Abdelwahed M;Zhou J;Monis A;Pitta MG;Gasmelseed N;Cabantous S;Zhao Y;Prata A;Brandt C;Elwali NE;Argiro L;Li Y
通讯作者：
Li Y