Brain energy metabolism, cognitive function and down-regulated oxidative phosphorylation in Alzheimer disease.
Brain energy metabolism, cognitive function and down-regulated oxidative phosphorylation in Alzheimer disease.
复制标题
阿尔茨海默病中的脑能量代谢、认知功能和氧化磷酸化下调。
DOI：
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发表时间：
1996
期刊：
影响因子：
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通讯作者：
K. Chandrasekaran
中科院分区：
文献类型：
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作者：
S. Rapoport;K. Hatanpää;D. Brady;K. Chandrasekaran
通过体内正电子发射断层扫描测量，阿尔茨海默病早期大脑葡萄糖利用减少，反映了神经元线粒体内氧化磷酸化基因表达的潜在可逆下调。这种下调可能发生在神经元能量需求首次因突触功能障碍或缺失而减少时。
Reduced brain glucose utilization in early stages of Alzheimer disease, as measured with in vivo positron emission tomography, reflects potentially reversible down-regulation of gene expression for oxidative phosphorylation within neuronal mitochondria. Such down-regulation may occur when neuronal energy demand is first reduced by synaptic dysfunction or loss.