Efficacy and mechanism of action of yin lai tang (lung-stomach treatment) in dyspepsia mouse infected by FM1 virus.
Efficacy and mechanism of action of yin lai tang (lung-stomach treatment) in dyspepsia mouse infected by FM1 virus.
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饮来汤（肺胃治疗）对fm1病毒感染消化不良小鼠的疗效及作用机制
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发表时间：
2013-11
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通讯作者：
谷晓红
中科院分区：
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作者：
谷晓红
本研究旨在观察银来汤对FM 1病毒感染的消化不良小鼠的疗效，并探讨其作用机制。选用4周龄雄性昆明种小鼠90只，体重12-14 g，随机分为9组，正常对照组、感染组、消化不良组、利巴韦林组、双黄连组、小儿消化不良片组、银来汤高剂量组、银来汤中剂量组、银来汤低剂量组，分别给予相应药物治疗，达到治疗目的。与正常组比较，除利巴韦林组肺指数显著增加（p <0.05）外，其余各组肺指数均显著增加（p <0.01）。消化不良组与其他组肺匀浆病毒滴度值差异无统计学意义（p > 0.05）。与正常组相比，其他各组动物呼吸道结构中存在不同程度的炎性细胞浸润，并且在感染和消化不良组中观察到血清IL-6、IL-10和TNF-α水平显著升高（p < 0.01），而血清IFN-γ水平显著降低（p < 0.01）。与单纯清胃法、单纯清肺法比较，肺胃结合法降低IL-6水平，差异无统计学意义（p > 0.05），升高IL-10水平，与单纯清肺法比较，差异有统计学意义（p < 0.05）。与单纯清胃法和单纯清肺法相比，肺胃同治法具有更好的疗效，并对促炎因子和抗炎因子的表达有影响。
The aim of this study was to assess the efficacy and elaborate the mechanism of action of Yin Lai Tang (Lung-Stomach Treatment) on dyspepsia mouse infected by FM1 virus. Ninety male, 4 week old Kunming mouse with 12-14 g weight, were randomly divided into 9 groups, i.e., normal, infected, dyspepsia, ribavirin, Shuanghuanglian, Children's indigestion tablet, YinLaiTang high dose, YinLaiTang middle dose and YinLaiTang low dose, and these groups had been treated by according drugs to get objectives. Compared with normal group, lung index significantly (p < 0.01) increased in all groups except ribavirin group where lung index obviously (p < 0.05) increased. There was non-significant (p > 0.05) difference in the values of lung homogenate virus titer between dyspepsia group and other groups. Compared to normal group, there was variable degree of inflammatory cell infiltrations in respiratory tract structures in the animals of other groups, and there was a significant (p < 0.01) increase in the level of serum IL-6, IL-10, and TNF-alpha in infected and dyspepsia group and significant (p < 0.01) decrease in the level of serum IFN-gamma was observed. Compared with single clearing stomach method and single clearing lung approach, lung-stomach treatment reduced the level of IL-6 with non-significant difference (p > 0.05) and increased the level of IL-10 obviously, and compared with the single clearing lung method, there was a significant difference (p < 0.05). Compared with the single clearing stomach method and the single clearing lung method, the lung-stomach treatment method had a better efficacy and showed effects on the expression of pro-inflammatory factor and anti-inflammatory factor.