Treatment recommendations for chronic knee osteoarthritis
Treatment recommendations for chronic knee osteoarthritis
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DOI：
10.1016/j.bpa.2020.06.006
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发表时间：
2020-09-01
影响因子：
4.8
通讯作者：
Urits, Ivan
中科院分区：
文献类型：
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作者：
Gress, Kyle;Charipova, Karina;Urits, Ivan
原发性骨关节炎 (OA) 是导致失能年数 (YLD) 的主要原因之一，阻碍了全球人口老龄化。大多数患者的骨关节炎被认为是过度使用损伤，导致关节退行性炎症，并伴随骨增生的形成。由于这种慢性疼痛疾病的性质不断升级，骨关节炎的治疗管理最初可以从更保守的方法开始。它最终可能导致更具侵入性的外科手术。目前，护理标准仍然是最初的保守治疗和生活方式的改变，包括减肥和同时抗炎治疗。注射经常用于升级护理，但相当多的患者最终诉诸全膝关节置换术。本综述将特别关注膝关节骨关节炎，简要概述危险因素和早期治疗，并深入探讨可缓解症状和恢复功能的侵入性干预措施。 (C) 2020 年由爱思唯尔有限公司出版。
Primary osteoarthritis (OA) hinders an aging global population as one of the leading causes of years-lost-to-disability (YLD). OA in most patients is considered to be an overuse injury that results in degenerative inflammation of the joints with the associated formation of bony outgrowths. Due to the escalating nature of this chronic pain disease, treatment management for OA can initially begin with a more conservative approach. It can eventually lead to more invasive surgical procedures. At present, the standard of care remains initial conservative management with lifestyle changes, including weight loss with concurrent anti-inflammatory regimens. Injections are frequently used for the escalation of care, but a significant number of patients ultimately resort to total knee arthroplasty. This review will focus specifically on knee OA, providing a brief overview of risk factors and early management and in-depth exploration of the invasive interventions that can offer symptomatic relief and return of function. (C) 2020 Published by Elsevier Ltd.