Proliferative activity of calcifying odontogenic cysts as evaluated by proliferating cell nuclear antigen labeling index
Proliferative activity of calcifying odontogenic cysts as evaluated by proliferating cell nuclear antigen labeling index
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增殖细胞核抗原标记指数评价牙源性钙化囊肿的增殖活性
DOI：
10.1111/j.1440-1827.1998.tb03854.x
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发表时间：
1998
影响因子：
2.2
通讯作者：
H. Nikai
中科院分区：
文献类型：
--
作者：
T. Takata;Yong Lu;I. Ogawa;Ming Zhao;Zhiqun Zhou;D. Mock;H. Nikai
牙源性钙化囊肿（COC）具有不同的组织学特征，因此，已提出了几个子类。为探讨卵巢上皮性癌不同组织学特征和亚型的增殖活性，对25例卵巢上皮性癌（21例良性，4例恶性）进行了增殖细胞核抗原（PCNA）标记指数（LI）测定。所有良性病例均为囊性病变，并进一步分为非增殖亚型（COCA; 4例）;增殖亚型（PS; 8例）;以及与牙瘤相关的COC（COCaO，nlne例）。癌性COC的PCNA U值（65.2 ± 5.6）明显高于良性COC（11.6 ± 9.0; P = 0.002）。在良性囊性COC的3种亚型中，非增殖型PCNA LI最低（6.8 ± 2.8），PS最高（17.2 ± 11.2）（P = 0.028）。在9例COCaO病例中，6例显示非增殖型上皮衬里（如PS），另外3例显示具有增殖特征的衬里（如PS）。COCaO组PCNA LI（14.3 ± 6.6）明显高于COCaO组（6.1 ± 4.3; P = 0.05）。结果表明，PCNA LI是鉴别良、恶性COC的一个可能的指标，无论何种亚型，内膜的增殖特征是影响COC增殖活性的主要因素。
The calcifying odontogenic cyst (COC) presents with diverse hlstologlcal features; thus, several subclasslfl‐cations have been proposed. To evaluate the slgnlficance of the various histological features and subtypes of COC from the perspectlve of proliferative activity, the proliferating cell nuclear antigen (PCNA) labellng index (LI; the percentage of positive nuclei) was assessed immunohistochemlcally in 25 cases of COC (21 benign and four malignant). All of the benign cases were of the cystic variety and further subclas‐sified into non‐proliferative subtype (NPS; four cases); proliferative subtype (PS; eight cases); and COC associated with odontoma (COCaO, nlne cases). The PCNA U of the mallgnant COC (65.2 ± 5.6) was slgnlflcantly higher than that of the benlgn COC (11.6 ± 9.0; P = 0.002). Non‐proliferative subtype (6.8 ± 2.8) showed the lowest PCNA LI and PS (17.2 ± 11.2) the highest of among the three subtypes of benign cystic COC (P = 0.028). In nine cases of COCaO, six showed epithelial lining of the non‐proliferative type as NPS and the other three had lining wlth proliferative features as PS. The PCNA LI of the latter COCaO group (14.3 ± 6.6) was significantly higher than that of the former (6.1 ± 4.3; P = 0.05), as Seen between PS and NPS. These results demonstrate that PCNA LI is a possible parameter for differentiating mallgnant COC from benign COC and, whatever the subtypes, the proliferative features In the lining are the main factor influencing the prollferatlng actlvity of COC.
人类实体恶性肿瘤中增殖细胞核抗原的免疫组织化学检测。
影响因子：
4.6
作者：
Robbins,BA;delaVega,D;Ogata,K;Tan,EM;Nakamura,RM
通讯作者：
Nakamura,RM