RELIABILITY OF URINARY CREATININE AS A PARAMETER USED TO ADJUST VALUES OF URINARY BIOLOGICAL INDICATORS
RELIABILITY OF URINARY CREATININE AS A PARAMETER USED TO ADJUST VALUES OF URINARY BIOLOGICAL INDICATORS
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DOI：
10.1007/bf00378371
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发表时间：
1985-01-01
影响因子：
3
通讯作者：
GHEZZI, I
中科院分区：
文献类型：
--
作者：
ALESSIO, L;BERLIN, A;GHEZZI, I
生物监测中使用的生物指示剂的值通常在[人]尿液的现场样品上确定。为了减少由于稀释引起的变化，通常的做法是根据参考参数（例如尿肌酸酐浓度和比重）来校正值。本研究的目的是验证肌酐是否具有必要的调整特性。肌酐水平不受利尿的影响，但与预期相反，代谢物的值显示出明显的个体内和个体间差异。这些数据对肌酐作为可用于调整目的的参数的有效性提出了严重质疑，并建议最好确定每种生物指标的调整是否实际上有用。最后，由于肌酐水平和比重值之间仅存在轻微相关性，因此得出结论，这2个参数不能无差别地用于调整。[The讨论了尿生物指示剂在职业医学中的应用。
The values of biological indicators used in biological monitoring are usually determined on spot samples of [human] urine. In order to reduce the variations due to dilution, it is common practice to correct the values according to reference parameters, such as urinary creatinine concentration and specific gravity. The aim of the present study was to verify whether creatinine possesses the necessary characteristics for adjustment. The levels of creatinine were not influenced by diuresis, but, contrary to what was expected, the values of the metabolite showed marked intraindividual and interindividual variations. These data raise serious doubts as to the validity of creatinine as a parameter that can be used for adjustment purposes, and suggest that it would be advisable to ascertain for each biological indicator whether in fact adjustment is of any use. Lastly, since there was only a slight correlation between creatinine levels and specific gravity values, it is concluded that these 2 parameters cannot be used indifferently for adjustment. [The use of urinary biological indicators in occupational medicine is discussed.].