Polymerization on the Rocks: Negatively-Charged α-amino acids
Polymerization on the Rocks: Negatively-Charged α-amino acids
复制标题
岩石上的聚合：带负电荷的 α-氨基酸
DOI：
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发表时间：
1998
期刊：
影响因子：
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通讯作者：
L. Orgel
中科院分区：
文献类型：
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作者：
A. Hill;C. Boehler;L. Orgel
带负电荷的氨基酸、谷氨酸、天冬氨酸和O-磷酸-L-丝氨酸的低聚物被羟基磷灰石和伊利石吸附，其亲和力随低聚物长度增加而增加。在吸附在羟基磷灰石上的低聚谷氨酸的情况下，额外的残留物的添加导致吸附强度增加约四倍。比7-mer长得多的低聚物被矿物顽强地保留下来。吸附在羟基磷灰石或伊利石上的短的低聚谷氨酸与活化的单体反复孵育导致至少45个单元长的低聚物的积累。天冬氨酸和O-磷酸-L-丝氨酸在羟基磷灰石上的相应反应在产生长的低聚物方面不太有效，而伊利石不能积累大量的天冬氨酸或O-磷酸-L-丝氨酸的长的低聚物。
Oligomers of the negatively-charged amino acids, glutamic acid, aspartic acid, and O-phospho-L-serine are adsorbed by hydroxylapatite and illite with affinities that increase with oligomer length. In the case of oligo-glutamic acids adsorbed on hydroxylapatite, addition of an extra residue results in an approximately four-fold increase in the strength of adsorption. Oligomers much longer than the 7-mer are retained tenaciously by the mineral. Repeated incubation of short oligo-glutamic acids adsorbed on hydroxylapatite or illite with activated monomer leads to the accumulation of oligomers at least 45 units long. The corresponding reactions of aspartic acid and O-phospho-L-serine on hydroxylapatite are less effective in generating long oligomers, while illite fails to accumulate substantial amounts of long oligomers of aspartic acid or of O-phospho-L-serine.