β1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response
β1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response
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DOI：
10.1016/s1074-7613(02)00281-9
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发表时间：
2002-03-01
期刊：
影响因子：
32.4
通讯作者：
Fässler, R
中科院分区：
文献类型：
--
作者：
Brakebusch, C;Fillatreau, S;Fässler, R
一些实验证据表明，β 1整合素介导的造血干细胞（HSC）粘附对于它们在骨髓（BM）中的功能是重要的。使用诱导缺失的β 1整合素基因限制在造血系统，我们表明，β 1整合素是不是必不可少的造血干细胞保留在骨髓，造血，和运输的淋巴细胞。然而，免疫与T细胞依赖性抗原导致几乎没有IgM的生产和增加分泌的IgG在突变小鼠，而T细胞非依赖性2型抗原的反应显示IgM和IgG的减少。这些数据表明，β 1整合素是必要的初级IgM抗体反应。
Several experimental evidences suggested that beta1 integrin-mediated adhesion of hematopoietic stem cells (HSC) is important for their function in the bone marrow (BM). Using induced deletion of the beta1 integrin gene restricted to the hematopoietic system, we show that beta1 integrin is not essential for HSC retention in the BM, hematopoiesis, and trafficking of lymphocytes. However, immunization with a T cell-dependent antigen resulted in virtually no IgM production and an increased secretion of IgG in mutant mice, while the response to a T cell-independent type 2 antigen showed decreases in both IgM and IgG. These data suggest that beta1 integrins are necessary for the primary IgM antibody response.