Seizure Incidence Rates in Children and Adults With Familial Cerebral Cavernous Malformations
Seizure Incidence Rates in Children and Adults With Familial Cerebral Cavernous Malformations
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DOI：
10.1212/wnl.0000000000012569
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发表时间：
2021-09-21
期刊：
影响因子：
9.9
通讯作者：
Kim, Helen
中科院分区：
文献类型：
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作者：
Fox, Christine K.;Nelson, Jeffrey;Kim, Helen
背景和目的 与家族性脑海绵状血管瘤 (FCCM) 相关的癫痫发作率尚未得到很好的描述，尤其是儿童。为了测量癫痫发作率、检查癫痫发作预测因子并描述癫痫严重程度，我们研究了加入脑血管畸形联盟 (BVMC) 的一组患有 FCCM 的儿童和成人。方法 在入组时和随访期间收集 BVMC 中患有 FCCM 的参与者的癫痫数据。我们根据年龄估计了癫痫发作的概率，并测试了脑海绵状血管瘤（CCM）计数或基因型是否与早期癫痫发作相关。结果 研究队列包括 479 例 FCCM 病例。入学时的中位年龄为 42.5 岁（四分位数范围 22.5-55.0），其中 19% 是儿童（
Background and Objectives Seizure incidence rates related to familial cerebral cavernous malformation (FCCM) are not well described, especially for children. To measure the seizure incidence rate, examine seizure predictors, and characterize epilepsy severity, we studied a cohort of children and adults with FCCM enrolled in the Brain Vascular Malformation Consortium (BVMC). Methods Seizure data were collected from participants with FCCM in the BVMC at enrollment and during follow-up. We estimated seizure probability by age and tested whether cerebral cavernous malformation (CCM) counts or genotype were associated with earlier seizure onset. Results The study cohort included 479 FCCM cases. Median age at enrollment was 42.5 years (interquartile range 22.5-55.0) and 19% were children (