Age and Gender-related Variations of Molecular and Phenotypic Parameters in A Cohort of Sicilian Population: from Young to Centenarians.
Age and Gender-related Variations of Molecular and Phenotypic Parameters in A Cohort of Sicilian Population: from Young to Centenarians.
复制标题
DOI：
10.14336/ad.2021.0226
复制
发表时间：
2021-10
影响因子：
7.4
通讯作者：
Candore G
中科院分区：
文献类型：
--
作者：
Aiello A;Accardi G;Aprile S;Caldarella R;Carru C;Ciaccio M;De Vivo I;Gambino CM;Ligotti ME;Vasto S;Zinellu A;Caruso C;Bono F;Candore G
人们的寿命越来越长，但寿命的延长并不意味着健康寿命的延长。因此，提高老年人的生活质量是一个优先事项。百岁老人在相对良好的健康状况下达到极长的寿命，避免或延迟致命或严重无效的疾病。因此，研究长寿过程对于解释健康和幸福的生物学机制非常重要，因为从这种方法中获得的知识可以提供有关如何减缓衰老的宝贵信息。我们进行了本研究，在一个很好的特点非常均匀的样本173人从西西西里，更新现有的文献中的一些表型方面的老化和长寿，并提出了一系列的价值观老年人。我们将从年轻人到百岁老人的5个年龄组进行了分类，以了解所研究的不同参数的年龄和性别相关变化。我们采用多维分析方法，收集了既往数据，并进行了人体测量、生物阻抗、分子、血液学、氧化和血液化学试验。本研究的一个重要证据是，几种生物标志物存在与年龄和性别相关的差异。事实上，在老龄化和其他医学研究中，性别差异似乎仍然没有得到充分的考虑和调查。此外，我们经常观察到年轻人和百岁老人之间的可比参数，而不是非老年人和百岁老人之间的可比参数，假设在系统恶化的衰减中有一种放缓，几乎随后出现逆转趋势。对百岁老人的研究为如何减缓衰老提供了重要的指示，对那些更容易受到疾病和残疾影响的人也有好处。在老龄化的世界中，识别使人长寿和健康的因素对转化医学具有巨大的意义。
People are living longer, but lifespan increase does not coincide with a boost in health-span. Thus, improving the quality of life of older people is a priority. Centenarians reach extreme longevity in a relatively good health status, escaping or delaying fatal or strongly invalidating diseases. Therefore, studying processes involved in longevity is important to explain the biological mechanisms of health and well-being, since knowledge born from this approach can provide valuable information on how to slow aging. We performed the present study in a well characterized very homogeneous sample of 173 people from Western Sicily, to update existing literature on some phenotypic aspects of aging and longevity and to propose a range of values for older people. We classified 5 age groups, from young adults to centenarians, to understand the age and gender-related variations of the different parameters under study. We collected anamnestic data and performed anthropometric, bioimpedance, molecular, haematological, oxidative, and hematochemical tests, adopting a multidimensional analysis approach. An important evidence of the present study is that there are differences related to both age and gender in several biomarkers. Indeed, gender differences seem to be still poorly considered and inadequately investigated in aging as well as in other medical studies. Moreover, we often observed comparable parameters between young and centenarians rather than non-agenarians and centenarians, hypothesizing a sort of slowdown, almost followed by a reversal trend, in the decay of systemic deterioration. The study of centenarians provides important indications on how to slow aging, with benefits for those who are more vulnerable to disease and disability. The identification of the factors that predispose to a long and healthy life is of enormous interest for translational medicine in an aging world.