Pathological characteristics, PCNA labeling index and DNA index in prognostic evaluation of patients with moderately differentiated hepatocellular carcinoma.
Pathological characteristics, PCNA labeling index and DNA index in prognostic evaluation of patients with moderately differentiated hepatocellular carcinoma.
复制标题
中分化肝细胞癌的病理特征、PCNA标记指数和DNA指数对预后评估的影响
DOI：
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发表时间：
2002
影响因子：
4.3
通讯作者：
Nong Zhang
中科院分区：
文献类型：
--
作者：
Wen;Guo;Jietian Xu;Xin;Yue;Nong Zhang
目的
探讨中分化型肝癌（HCC）的病理特征、增殖细胞核抗原标记指数（PCNA LI）和DNA指数（DI）与预后的关系。
方法
本文分析了51例中分化肝癌的临床随访资料与病理特征的关系。同时采用免疫组化法检测肝癌细胞PCNA LI，Feulgen染色结合图像分析技术检测DI。
结果
单个肿瘤结节、直径小于5cm、无瘤栓、无子结节和坏死者预后相对较好;整倍体HCC患者预后较好;异倍体患者中DI 1.5者预后较好<1.5 had better prognosis than the cases with DI>; PCNA-LI越高预后越差。DI的增高与PCNA-LI的增高相关，两者均与肿瘤的病理改变相关。
结论
综合分析肿瘤组织病理学特征、DI和PCNA-LI对判断HCC患者预后有一定意义。
AIM
To study the relationship between prognosis and pathological characteristics, proliferating cell nuclear antigen labeling index (PCNA-LI) and DNA index (DI) in patients with moderately differentiated hepatocellular carcinoma(HCC).
METHODS
51 cases of moderately differentiated HCC were analyzed with respect to the relation between their clinical follow-up data and pathological characteristics. Meanwhile, PCNA-LI of HCC cells was detected by immunohistochemistry assay and DI was measured by Feulgen staining and automatic image analysis technique.
RESULTS
Patients with a single tumor nodule, less than 5 cm in diameter, no tumor emboli, no daughter nodules and necrosis had relatively better prognosis; patients with euploidy HCC had better prognosis than those with aneuploidy; among the aneuploidy patients those with DI<1.5 had better prognosis than the cases with DI>1.5; The higher the PCNA-LI, the worse would be the prognosis. The increase in DI was correlated with the increase in PCNA-LI, and both of them were correlated with the pathological changes of the tumor.
CONCLUSION
A composite analysis of the pathological characteristics of tumor tissue, DI and PCNA-LI might be useful in predicting the prognosis of HCC patients.
影响因子：
3.5
作者：
Ohmiya, N;Matsumoto, S;Perucho, M
通讯作者：
Perucho, M