Differential sensitivity of two adenocarcinoma xenografts to the anti-vascular drugs combretastatin A4 phosphate and 5,6-dimethylxanthenone-4-acetic acid, assessed using MRI and MRS
Differential sensitivity of two adenocarcinoma xenografts to the anti-vascular drugs combretastatin A4 phosphate and 5,6-dimethylxanthenone-4-acetic acid, assessed using MRI and MRS
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DOI：
10.1002/nbm.723
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发表时间：
2002-04-01
影响因子：
2.9
通讯作者：
Brindle, KM
中科院分区：
文献类型：
--
作者：
Beauregard, DA;Pedley, RB;Brindle, KM
两种抗血管药物的作用。考布他汀A4磷酸盐（CA 4P）。和5，6-二甲基咕吨酮-4-乙酸（DMXAA）对移植在SCID小鼠中的两个人结肠腺癌的灌注的影响。使用非侵入性磁共振成像（MRI）和波谱技术（MRS）进行了长达3小时的评估，GdDTPA流入的MRI测量结果显示，CA 4 P治疗对HT 29肿瘤的灌注影响不大。局部（PMRS）-P-31测量也表明，该药物对肿瘤细胞能量状态没有显著影响，如从无机磷酸盐（P-i）和核苷三磷酸的信号积分比评估的。然而. DMXAA治疗后。灌注减少，P-i/NTP比值增加。表明HT 29肿瘤对该药物的作用敏感。LS 174 T肿瘤模型对CA 4P和DMXAA均敏感。以GdDTPA流入量和P-i/NTP比值变化为标准。版权所有（C）2002年约翰威利儿子。公司
The effects of two anti-vascular agents. combretastatin A4 phosphate (CA4P). and 5.6-dimethylxanthenone-4-acetic acid (DMXAA), on the perfusion Of two human colon adenocarcinomas implanted in SCID mice. were assessed for up to 3 h using non-invasive magnetic resonance imaging (MRI) and spectroscopy techniques (MRS), MRI measurements of GdDTPA inflow showed that treatment with CA4P had little effect on the perfusion of HT29 tumours. Localized (PMRS)-P-31 measurements also showed that the drug had no significant effect on tumour cell energy status, as assessed from the ratio of the integrals of the signals from inorganic phosphate (P-i) and nucleoside triphosphates. However. after treatment with DMXAA. perfusion was reduced and the P-i/NTP ratio increased. indicating that the HT29 tumour is susceptible to the action of this drug. The LS174T tumour model was susceptible to both CA4P and DMXAA. using the criteria of changes in GdDTPA inflow and P-i/NTP ratio. Copyright (C) 2002 John Wiley Sons. Ltd.