The performance of gamma- and EtO-sterilised UHMWPE acetabular cups tested under severe simulator conditions. Part 2: wear particle characteristics with isolation protocols
The performance of gamma- and EtO-sterilised UHMWPE acetabular cups tested under severe simulator conditions. Part 2: wear particle characteristics with isolation protocols
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DOI：
10.1016/s0142-9612(03)00264-3
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发表时间：
2003-10-01
期刊：
影响因子：
14
通讯作者：
Toni, A
中科院分区：
文献类型：
--
作者：
Affatato, S;Bersaglia, G;Toni, A
超高分子量聚乙烯（UHMWPE）在过去三十年中一直用于全关节置换术。尽管最近假体设计取得了进步，但UHMWPE的磨损仍然是一个严重的临床问题;磨损碎屑的释放可能导致骨质溶解和植入物松动。控制聚乙烯的质量对于提高其耐磨性至关重要，应避免加工、制造或灭菌引起的任何潜在不良影响。评价灭菌方法（伽马辐照和环氧乙烷（EtO）处理）和第三体颗粒的影响。在存在第三体聚甲基丙烯酸甲酯（PMMA）颗粒的小牛血清中，在髋关节模拟器中对伽马和EtO灭菌的UHMWPE髋臼杯与CoCrMo股骨头进行了250万次循环的测试。提出了一种不需要超离心的方法，用于从血清润滑剂中分离聚乙烯磨损碎屑。SEM分析可以确定碎片的形状和形态，并假设本研究中的磨损机制。磨损碎片的形态特征与临床结果一致，使髋关节模拟器功能得到验证。显微拉曼光谱结合PLS分析表明，在体外测试过程中的机械摩擦导致所有髋臼杯的结晶度发生显著变化。观察到EtO灭菌杯的最显著变化，其显示出最高的重量损失。(C)2003爱思唯尔科技有限公司版权所有。
Ultra-high molecular-weight polyethylene (UHMWPE) has been used in total joint replacement for the last three decades. Despite the recent advancements in prosthesis design, the wear of UHMWPE remains a serious clinical problem; the release of wear debris may induce osteolysis and implant loosening. Controlling the quality of the polyethylene is essential to improve its wear resistance and any potential adverse effect caused by processing, manufacturing or sterilisation should be avoided.To evaluate the influence of the sterilisation method (gamma-irradiation and ethylene oxide (EtO)-treatment) and third-body particles. gamma- and EtO-sterilised UHMWPE acetabular cups were tested against CoCrMo femoral heads in a hip joint simulator run for 2.5 million cycles in bovine calf serum in the presence of third-body polymethyltnethacrylate (PMMA) particles.A method not requiring ultra-centrifugation has been proposed for the isolation of polyethylene wear debris from the serum lubricant. SEM analysis allowed debris shape and morphology to be determined, and the wear mechanism operating in this study to be hypothesised, The morphological features of the wear debris were in agreement with clinical findings, enabling the hip simulator function to be validated.Micro-Raman spectroscopy coupled to PLS analysis showed that the mechanical friction during in vitro tests induced significant crystallinity changes in all the cups. The most significant changes were observed for the EtO-sterilised cups, which showed the highest weight loss. (C) 2003 Elsevier Science Ltd. All rights reserved.