"Myelodysplasia," myeloneuropathy, and copper deficiency
"Myelodysplasia," myeloneuropathy, and copper deficiency
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DOI：
10.4065/80.7.943
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发表时间：
2005-07-01
影响因子：
8.9
通讯作者：
Phyliky, RL
中科院分区：
文献类型：
--
作者：
Kumar, N;Elliott, MA;Phyliky, RL
我们描述了一个疑似骨髓增生异常综合征的患者，其发展与类似亚急性联合变性但无维生素B-12缺乏症的神经系统疾病有关。最终，血液学表现和神经系统综合征与严重的铜缺乏有关。铜替代治疗可迅速完全逆转血液学异常。血清铜测定应包括在贫血和白细胞减少症的患者病因不明谁相关的脊髓神经病的工作了。血液学表现类似铁粒幼细胞性贫血或骨髓增生异常综合征。即使没有摄入外源性锌，高锌血症也可能是伴随的异常。铜缺乏的原因可能并不明显。
We describe a patient with a suspected myelodysplastic syndrome that developed in association with a neurologic disorder resembling subacute combined degeneration but without vitamin B-12 deficiency. Ultimately, the hematologic manifestations and the neurologic syndrome were linked to severe copper deficiency. Prompt and complete reversal of the hematologic abnormalities occurred with copper replacement. Serum copper determination should be included in the work-up of patients with anemia and leukopenia of unclear etiology who have associated myeloneuropathy. The hematologic picture can resemble sideroblastic anemia or myelodysplastic syndrome. Hyperzincemia can be an accompanying abnormality even without exogenous zinc Ingestion. The reason for the copper deficiency may not be evident.