Regulating dual temperature- and pH-responsibility constructed from core-shell mesoporous hybrid silica (P(NIPAM-co-AA)@BMMs) via adjusting AA incorporation onto NIPAM
Regulating dual temperature- and pH-responsibility constructed from core-shell mesoporous hybrid silica (P(NIPAM-co-AA)@BMMs) via adjusting AA incorporation onto NIPAM
复制标题
通过调整 NIPAM 上 AA 的掺入来调节由核壳介孔杂化二氧化硅 (P(NIPAM-co-AA)@BMMs) 构建的双重温度和 pH 响应
DOI：
10.1080/00914037.2018.1466132
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发表时间：
2019-05-24
影响因子：
3.2
通讯作者：
Wu, Xia
中科院分区：
文献类型：
--
作者：
Jin, Xiaoqi;Wang, Qian;Wu, Xia
摘要 以双峰介孔二氧化硅材料（BMMs）为核，pH和温度双响应型聚（N-异丙基丙烯酰胺）-共聚（丙烯酸）（P（NIPAM-co-AA））共聚物为壳，通过种子聚合法成功合成了具有核壳结构的介孔杂化二氧化硅（P@BMMs）。同时，通过X射线衍射、N2吸附-解吸等温线、扫描电子显微镜、透射电子显微镜、傅里叶变换红外、紫外可见漫反射光谱、小角X射线散射（SAXS）、动态光散射和热重分析技术对所得P@BMMs进行了物理化学和形态表征。结果表明，P(NIPAM-co-AA) 成功涂覆到用过的 BMM 的介孔表面上，同时仍然保留了所得 P@BMM 的均匀介孔结构。以布洛芬（IBU）为模型药物，探讨了P（NIPAM-co-AA）壳对IBU释放动力学的影响，其性能表明P@BMMs纳米颗粒具有明显的热/pH响应特性，可以通过调节AA与NIPAM的质量比来调节该特性，并且其IBU释放动力学曲线有利于Korsmeyer-Peppas模型。特别地，采用SAXS模式来评估P@BMMs随释放时间的分形演化，显示在0.25-24小时的释放时间内质量分形值从2.89下降到2.56。图解摘要
Abstract The mesoporous hybrid silicas (P@BMMs) with core-shell structure were successfully synthesized via seed polymerization method using bimodal mesoporous silica materials (BMMs) as core and dual pH- and temperature-responsive poly(N-isopropylacryl-acrylamide)-co-poly(acrylic acid) (P(NIPAM-co-AA)) copolymer as shell. Meanwhile, the obtained P@BMMs were physicochemically and morphologically characterized via X-ray diffraction, N2 adsorption-desorption isotherms, scanning electron microscopy, transmission electron microscopy, Fourier transform infrared, ultraviolet visible diffused reflection spectrum, small angle X-ray scattering (SAXS), dynamic light scattering, and thermogravimetric analysis techniques. The results indicated that P(NIPAM-co-AA) was successfully coated onto the mesoporous surface of used BMMs, while the uniform mesoporous structure of obtained P@BMMs was still preserved. Using ibuprofen (IBU) as a model drug, the influence of the P(NIPAM-co-AA) shell on the release kinetics of IBU was explored, and its performances elucidated that the P@BMMs nanoparticles presented an apparent thermo/pH-responsive properties, which could be regulated via adjusting mass ratio of AA to NIPAM, and their IBU-release kinetic profiles were favorable to Korsmeyer-Peppas model. Specially, SAXS patterns were employed to evaluate the fractal evolution of P@BMMs along with releasing time, showing the decline tendency for mass fractal value from 2.89 to 2.56 during the release time of 0.25–24 h. Graphical Abstract