Atopic dermatitis
Atopic dermatitis
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DOI：
10.1016/j.jaci.2005.10.018
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发表时间：
2006-02-01
影响因子：
14.2
通讯作者：
Leung, DYM
中科院分区：
文献类型：
--
作者：
Boguniewicz, M;Leung, DYM
特应性皮炎是一种常见的慢性炎症性皮肤病，通常发生在哮喘和过敏性疾病（如食物过敏或过敏性鼻结膜炎）之前。病理生理学涉及由促炎细胞因子和趋化因子协调的驻留细胞和浸润细胞之间的一系列复杂的相互作用。抗微生物肽的缺乏可能导致特应性皮炎中所见的微生物定植或感染的倾向。新的治疗方法包括使用局部类固醇作为维持治疗和使用局部钙调磷酸酶抑制剂进行早期干预，局部类固醇用作补救治疗。
Atopic dermatitis is a common chronic inflammatory skin disease often preceding the development of asthma and allergic disorders, such as food allergy or allergic rhinoconjunctivitis. Pathophysiology involves a complex series of interactions between resident and infiltrating cells orchestrated by proinflammatory cytokines and chemokines. A deficiency of antimicrobial peptides might contribute to the propensity for colonization or infection by microbial organisms seen in atopic dermatitis. New treatment approaches include use of topical steroids as maintenance therapy and use of topical calcineurin inhibitors for early intervention with topical steroids used as rescue therapy.