Structurally diverse diterpenoids from Trigonostemon howii
Structurally diverse diterpenoids from Trigonostemon howii
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Trigonostemon howii 中结构多样的二萜类化合物
DOI：
10.1080/14786419.2018.1462184
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发表时间：
2019
影响因子：
2.2
通讯作者：
Fu Yan Hui
中科院分区：
文献类型：
--
作者：
Liu Yan Ping;Wen Qing;Hu Shi;Ma Yan Lei;Jiang Zhi Hua;Tang Jin Ying;Fu Yan Hui
通过对胡卢巴茎和叶的植物化学研究，分离出一种新的松香烷型二萜类化合物胡卢巴亚胺A（trigohowimine A）（1），沿着7种已知结构多样的二萜类化合物（2-8）。通过波谱方法对化合物1的结构进行了鉴定，并与文献报道的数据进行了比较。评价了新化合物1对HL-60、SMMC-7721、A-549、MCF-7和SW 480五种人癌细胞系的细胞毒性。化合物1对多种人癌细胞株均有明显的抑制作用，IC_（50）为0.82 ~ 8.53 μM。
Phytochemical investigation on the stems and leaves ofTrigonostemon howiiresulted in the isolation of a new abietane diterpenoid, trigohowimine A (1), along with seven known structurally diverse diterpenoids (2–8). The structure of1was elucidated by extensive spectroscopic methods and the known compounds were identified by comparison with data reported in the literature. New compound1was evaluated for its cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480. Compound1showed significant inhibitory effects against various human cancer cell lines with IC50values ranging from 0.82 to 8.53 μM.