Proton and calcium pumping P-type ATPases and their regulation of plant responses to the environment
Proton and calcium pumping P-type ATPases and their regulation of plant responses to the environment
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DOI：
10.1093/plphys/kiab330
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发表时间：
2021-07-27
期刊：
影响因子：
7.4
通讯作者：
Palmgren, Michael
中科院分区：
文献类型：
--
作者：
Fuglsang, Anja T.;Palmgren, Michael
植物质膜H ~+-ATP酶和Ca ~（2+）-ATP酶分别维持细胞质中较低的H ~+和Ca ~（2+）浓度，对植物的生长发育至关重要。这些低浓度允许质膜H+-ATP酶作为生电电压状态，并且允许Ca 2 +-ATP酶作为基于Ca 2+的信号转导中的“关闭”机制。虽然这些泵是自动调节细胞质浓度的H+和Ca 2+，分别，他们也受到精致的调节，以响应生物和非生物事件的环境。这两种类型的泵的共同范例是存在末端调节（R）结构域，其作为自身抑制剂起作用，可以通过多种手段（包括磷酸化）中和。一幅图片正在出现，其中一些在这些R域的磷酸化似乎是高度，几乎不断磷酸化，而其他人似乎是受动态磷酸化。因此，有些网站可能会作为主要开关，而其他人可能只是减少活动。在这里，我们提供了相关的运输系统的概述，并讨论了最近的进展，解决他们的关系，外部刺激和生理适应。
Plant plasma membrane H+-ATPases and Ca2+-ATPases maintain low cytoplasmic concentrations of H+ and Ca2+, respectively, and are essential for plant growth and development. These low concentrations allow plasma membrane H+-ATPases to function as electrogenic voltage stats, and Ca2+-ATPases as "off' mechanisms in Ca2+-based signal transduction. Although these pumps are autoregulated by cytoplasmic concentrations of H+ and Ca2+, respectively, they are also subject to exquisite regulation in response to biotic and abiotic events in the environment. A common paradigm for both types of pumps is the presence of terminal regulatory (R) domains that function as autoinhibitors that can be neutralized by multiple means, including phosphorylation. A picture is emerging in which some of the phosphosites in these R domains appear to be highly, nearly constantly phosphorylated, whereas others seem to be subject to dynamic phosphorylation. Thus, some sites might function as major switches, whereas others might simply reduce activity. Here, we provide an overview of the relevant transport systems and discuss recent advances that address their relation to external stimuli and physiological adaptations.