IgE and non-IgE mediated allergic disorders in systemic lupus erythematosus
IgE and non-IgE mediated allergic disorders in systemic lupus erythematosus
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DOI：
10.1136/ard.57.11.660
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发表时间：
1998-11-01
影响因子：
27.4
通讯作者：
Powell, RJ
中科院分区：
文献类型：
--
作者：
Morton, S;Palmer, B;Powell, RJ
目的：了解系统性红斑狼疮(SLE)患者中IgE和非IgE介导的变态反应性疾病的患病率。方法对49例SLE患者(均符合修订后的ARA标准)和98例健康、年龄、性别匹配的对照组(通过2个城市全科医生和1个农村全科医生随机抽取)进行电话访谈，以筛选过敏病史。有变应性鼻炎、哮喘或特应性湿疹病史的受试者接受皮肤点刺试验，以确定潜在的IgE介导的疾病。结果条件Logistic回归分析显示，SLE患者和对照组变态反应性疾病的发生率没有显著差异(优势比(OR)0.92，95%可信区间(CI)0.45，1.86)。此外，对IgE介导的特应性疾病受试者进行的亚组分析显示，病例和对照组患这些疾病的风险相似(OR 0.90，95%CI 0.41，1.96)。结论--与以前的报道相比，本研究表明SLE患者患IgE介导/相关变态反应性疾病的风险并未增加。
Objective-To ascertain the prevalence of IgE and non-IgE mediated allergic disorders in patients with systemic lupus erythematosus (SLE).Methods-49 SLE cases (all satisfying at least four "Revised ARA Criteria") and 98 healthy, age, and sex matched controls (randomly selected through two urban general practices and one rural general practice) were interviewed by telephone to screen for a history of allergy. Subjects with a history of allergic rhinitis, asthma or atopic eczema then underwent skin prick testing to confirm underlying IgE mediated disease.Results-Analysis of the data by conditional logistic regression revealed no significant difference in frequency of allergic disorders in SLE cases and controls (odds ratio (OR) 0.92, 95% confidence intervals (CI) 0.45, 1.86). In addition a subgroup analysis of subjects with IgE mediated associated atopic disorders, showed that cases and controls were at a similar risk of having these conditions (OR 0.90, 95% CI 0.41, 1.96).Conclusions-This study suggests that people with SLE are not at an increased risk of IgE mediated/associated allergic disorders, in contrast with previous reports.