Upregulation of interleukin‐1β/transforming growth factor‐β1 and hypoxia relate to molecular mechanisms underlying immobilization‐induced muscle contracture
Upregulation of interleukin‐1β/transforming growth factor‐β1 and hypoxia relate to molecular mechanisms underlying immobilization‐induced muscle contracture
复制标题
白细胞介素-1β/转化生长因子-β1的上调和缺氧与固定引起的肌肉挛缩的分子机制有关
作者：
Y. Honda;Junya Sakamoto;J. Nakano;H. Kataoka;R. Sasabe;Kyo Goto;Miho Tanaka;T. Origuchi;T. Yoshimura;M. Okita
前言：在这项研究中，我们研究了大鼠肌肉痉挛的分子机制。方法：将大鼠分为制动组和对照组，取左右两侧比目鱼肌进行分析。结果：各时间点固定组CD11b、α-SMA蛋白、IL-1mRNA、β、β1mRNA、I型、III型胶原蛋白表达水平均显著高于对照组。在4周时，固定组HIF-1α表达水平显著高于对照组。此外，固定组在4周时HIF-1、α，α-SMA和I型胶原水平显著高于1周和2周。结论：在固定化早期，巨噬细胞上调IL-1β/转化生长因子-β1可能促进成纤维细胞分化，从而影响肌挛缩症。比目鱼肌在制动后期出现低氧，提示低氧影响肌肉痉挛的进展。肌肉神经52：419-427,2015
Introduction: In this study we investigated the molecular mechanism underlying muscle contracture in rats. Methods: The rats were divided into immobilization and control groups, and soleus muscles of the right and left sides were selected for analyses. Results: The levels of CD11b and α‐SMA protein, IL‐1β, and TGF‐β1 mRNA, and type I and III collagen protein and mRNA were significantly greater in the immobilization group than in the control group at all time‐points. HIF‐1α mRNA levels were significantly higher in the immobilization group at 4 weeks. Moreover, HIF‐1α, α‐SMA, and type I collagen levels were significantly higher at 4 weeks than at 1 and 2 weeks in the immobilization group. Conclusions: In the early stages of immobilization, upregulation of IL‐1β/TGF‐β1 via macrophages may promote fibroblast differentiation that could affect muscle contracture. The soleus muscle became hypoxic in the later stages of immobilization, suggesting that hypoxia influences the progression of muscle contracture. Muscle Nerve 52:419–427, 2015
影响因子：
14.2
作者：
Gomes, I;Mathur, SK;Ackerman, SJ
通讯作者：
Ackerman, SJ