Association between cognitive performance and cortical glucose metabolism in patients with mild Alzheimer's disease
Association between cognitive performance and cortical glucose metabolism in patients with mild Alzheimer's disease
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DOI：
10.1159/000088558
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发表时间：
2005-01-01
影响因子：
2.4
通讯作者：
Hampel, H
中科院分区：
文献类型：
--
作者：
Bokde, ALW;Teipel, SJ;Hampel, H
背景：使用正电子发射断层扫描 (PET) 通过葡萄糖代谢在体内测量阿尔茨海默病 (AD) 的神经元和突触功能。目的：我们假设 PET 测量的神经元激活是比休息期间的活动更敏感的神经元功能障碍指标。我们研究了通过简易精神状态检查（MMSE）测量的痴呆严重程度与葡萄糖代谢之间的相关性是否是脑萎缩的产物。方法：使用[F-18]氟脱氧葡萄糖 PET 测量 13 名轻至中度 AD 患者（MMSE 评分≥ 17）在休息和由于视听刺激而激活时的葡萄糖代谢。 PET 数据针对脑萎缩进行了校正。结果：在休息状态下，葡萄糖代谢与 MMSE 评分主要在后扣带回和顶叶相关。对于激活条件，主要和关联视听区域内存在其他相关性。在校正脑萎缩后，大多数局部最大值仍然显着。结论：与静息 PET 相比，视听刺激期间测量的 PET 活性对 AD 患者葡萄糖代谢功能变化更敏感。葡萄糖代谢和 MMSE 评分之间的关联不依赖于脑萎缩。版权所有 (C) 2005 S. Karger AG，巴塞尔。
Background: Neuronal and synaptic function in Alzheimer's disease (AD) is measured in vivo by glucose metabolism using positron emission tomography (PET). Objective: We hypothesized that neuronal activation as measured by PET is a more sensitive index of neuronal dysfunction than activity during rest. We investigated if the correlations between dementia severity as measured with the Mini Mental State Examination (MMSE) and glucose metabolism are an artifact of brain atrophy. Method: Glucose metabolism was measured using [F-18]fluorodeoxyglucose PET during rest and activation due to audiovisual stimulation in 13 mild to moderate AD patients (MMSE score >= 17). PET data were corrected for brain atrophy. Results: In the rest condition, glucose metabolism was correlated with the MMSE score primarily within the posterior cingulate and parietal lobes. For the activation condition, additional correlations were within the primary and association audiovisual areas. Most local maxima remained significant after correcting for brain atrophy. Conclusion: PET activity measured during audiovisual stimulation was more sensitive to functional alterations in glucose metabolism in AD patients compared to the resting PET. The association between glucose metabolism and MMSE score was not dependent on brain atrophy. Copyright (C) 2005 S. Karger AG, Basel.