SERUM AMYLOID-A-PROTEIN CONCENTRATION IN RHEUMATOID-ARTHRITIS AND ITS ROLE IN MONITORING DISEASE-ACTIVITY
SERUM AMYLOID-A-PROTEIN CONCENTRATION IN RHEUMATOID-ARTHRITIS AND ITS ROLE IN MONITORING DISEASE-ACTIVITY
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DOI：
10.1136/ard.42.6.665
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发表时间：
1983-01-01
影响因子：
27.4
通讯作者：
DIEPPE, PA
中科院分区：
文献类型：
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作者：
CHAMBERS, RE;MACFARLANE, DG;DIEPPE, PA
测定185名类风湿性关节炎患者的血清淀粉样蛋白A蛋白（SAA）、C反应蛋白（CRP）和α 1-酸性糖蛋白（α 1-AGP）的血清浓度。SAA和CRP浓度在正常范围内和正常范围以上均具有良好的相关性（r = 0.86），尽管SAA的增量大于CRP。SAA水平正常的所有患者也具有正常的CRP和α 1-AGP浓度。相比之下，在40%的CRP和α 1-AGP浓度正常的患者中，SAA升高，有时显着升高。这些患者的疾病活动性的临床和血清学评估与伴随CRP水平升高的患者无显著差异。SAA显然是比CRP更敏感的炎症标志物。SAA作为炎症性疾病活动的监测测量的作用进行了讨论。
The serum concentrations of serum amyloid-A protein (SAA), C-reactive protein (CRP), and .alpha.1-acid glycoprotein (.alpha.1-AGP) were measured in 185 patients with rheumatoid arthritis. SAA and CRP concentrations correlated well (r = 0.86) both within and above the normal ranges, though SAA showed a greater incremental increase than CRP. All patients with normal SAA levels also had normal CRP and .alpha.1-AGP concentrations. In contrast, in 40% of patients with normal CRP and .alpha.1-AGP concentrations the SAA was raised, sometimes markedly so. The clinical and serological assessments of disease activity in these patients were not significantly different from those with concomitantly raised levels of CRP. SAA apparently is a more sensitive marker of inflammation than is CRP. The role of the measurement of SAA as a monitor for inflammatory disease activity is discussed.