Oxidative stress and glycemic regulation
Oxidative stress and glycemic regulation
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DOI：
10.1016/s0026-0495(00)80082-7
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发表时间：
2000-02-01
影响因子：
9.8
通讯作者：
Ceriello, A
中科院分区：
文献类型：
--
作者：
Ceriello, A
氧化应激是公认的糖尿病并发症的发病机制。高血压是一个众所周知的原因，增强自由基浓度，而氧化应激参与血糖调节仍有争议。葡萄糖转运是从胰岛素与其自身质膜受体相互作用开始并以细胞内葡萄糖代谢结束的级联事件。在这一系列复杂的事件中，每一步都起着重要的作用，并且可以被氧化应激的负面影响所抑制。几项研究表明，血糖水平的急性增加可能会损害生物体中许多系统的生理稳态。急性高血糖症发挥这些作用的机制可以在自由基的产生中确定。有人认为，胰岛素抵抗可能伴随着细胞内自由基的产生。在体外培养的脂肪细胞中，胰岛素增加过氧化氢的产生，这已被证明是模仿胰岛素的作用。这些数据使我们能够假设，高胰岛素血症和自由基之间的恶性循环可能正在运作：胰岛素抵抗可能会导致血浆自由基浓度升高，这反过来可能是胰岛素作用恶化的原因，高血糖症是一个促成因素。支持这一假设的数据是可用的，维生素E改善健康，老年人和非胰岛素依赖型糖尿病受试者的胰岛素作用。服用维生素C也可以获得类似的结果。Copyright（C）2000 by W.B.桑德斯公司
Oxidative stress is an acknowledged pathogenetic mechanism in diabetic complications. Hyperglycemia is a widely known cause of enhanced free radical concentration, whereas oxidative stress involvement in glycemic regulation is still debated. Glucose transport is a cascade of events starting from the interaction of insulin with its own receptor at the plasma membrane and ending with intracellular glucose metabolism. In this complex series of events, each step plays an important role and can be inhibited by a negative effect of oxidative stress. Several studies show that an acute increase in the blood glucose level may impair the physiological homeostasis of many systems in living organisms. The mechanisms through which acute hyperglycemia exerts these effects may be identified in the production of free radicals. It has been suggested that insulin resistance may be accompanied by intracellular production of free radicals. In adipocytes cultured in vitro, insulin increases the production of hydrogen peroxide, which has been shown to mimic the action of insulin. These data allow us to hypothesize that a vicious circle between hyperinsulinemia and free radicals could be operating: insulin resistance might cause elevated plasma free radical concentrations, which, in turn, might be responsible for a deterioration of insulin action, with hyperglycemia being a contributory factor. Data supporting this hypothesis are available, Vitamin E improves insulin action in healthy, elderly, and non-insulin-dependent diabetic subjects. Similar results can be obtained by vitamin C administration. Copyright (C) 2000 by W.B. Saunders Company.