The role of the preSMA and the rostral cingulate zone in internally selected actions
The role of the preSMA and the rostral cingulate zone in internally selected actions
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DOI：
10.1016/j.neuroimage.2007.06.018
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发表时间：
2007-10-01
期刊：
影响因子：
5.7
通讯作者：
Prinz, Wolfgang
中科院分区：
文献类型：
--
作者：
Mueller, Veronika A.;Brass, Marcel;Prinz, Wolfgang
在日常生活中，人们可以区分主要由内部引导的行为和主要由外部事件引导的行为。研究内部引导动作的神经相关性的 FMRI 研究通常报告头端扣带区 (RCZ) 以及前 SMA 的激活最大值。然而，相关对比常常因不同条件之间的知觉和运动差异而混淆。在当前的研究中，我们使用避免任何此类知觉或运动混淆的范例重新研究了内部与外部选择的动作的神经相关性。通过这样做，我们希望解决尚未解决的问题：preSMA 和 RCZ 在内部引导行动中发挥何种不同作用。受试者被要求在等时起搏信号之间的中点按下左或右按键（一系列“X”呈现在注视点的左侧或右侧）。在内部选择条件下，IX'的位置由受试者自由选择的前一个按键位置决定。相反，在外部选择的条件下，“X”的位置规定了后续按键响应的位置。我们发现，与外部选择的动作相比，内部选择的动作对 RCZ 的激活有差异。与之前的研究相比，preSNIA 在两种条件下表现出相同的活性，因此没有区分两种作用选择模式。这表明 RCZ 在内部选择的行动中发挥着主要作用。 (C) 2007 Elsevier Inc. 保留所有权利。
In everyday life, one can differentiate between actions that are primarily internally guided and actions that are primarily guided by external events. FMRI studies investigating the neural correlates of internally guided actions usually report activation maxima in the rostral cingulate zone (RCZ) as well as the preSMA. However, the pertinent contrasts were often confounded by perceptual and motor differences between the different conditions. In the current study, we reinvestigated the neural correlates of internally vs. externally selected actions using a paradigm that avoids any such perceptual or motor confound. By doing so, we wanted to address the yet unsolved question which differential role the preSMA and RCZ play in internally guided actions. Subjects were required to make left or right key presses at the midpoint between isochronous pacing signals (a sequence of 'X's presented to the left or the right of the fixation point). In the internally selected condition, the location of the IX' was determined by the location of the preceding key press that the subjects selected freely. In the externally selected condition, by contrast, the location of the 'X' prescribed the location of the subsequent key press response. We found that the RCZ was differentially activated by internally as compared to externally selected actions. In contrast to previous studies, the preSNIA showed equal activity in both conditions and thus did not differentiate between the two modes of action selection. This suggests a primary role for the RCZ in internally selected actions. (C) 2007 Elsevier Inc. All rights reserved.