Treatment of vaginitis caused by Candida glabrata:: Use of topical boric acid and flucytosine
Treatment of vaginitis caused by Candida glabrata:: Use of topical boric acid and flucytosine
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DOI：
10.1067/s0002-9378(03)00726-9
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发表时间：
2003-11-01
影响因子：
9.8
通讯作者：
Leaman, D
中科院分区：
文献类型：
--
作者：
Sobel, JD;Chaim, W;Leaman, D
OBJECTIVE: The purpose of this study was to review the treatment outcome and safety of topical therapy with boric acid and flucytosine in women with Candida glabrata vaginitis.STUDY DESIGN: This was a retrospective review of case records of 141 women with positive vaginal cultures of C glabrata at two sites, Wayne State University School of Medicine and Ben Gurion University.RESULTS: The boric acid regimen, 600 mg daily for 2 to 3 weeks, achieved clinical and mycologic success in 47 of 73 symptomatic women (64%) in Detroit and 27 of 38 symptomatic women (71%) in Beer Sheba. No advantage was observed in extending therapy for 14 to 21 days. Topical flucytosine cream administered nightly for 14 days was associated with a successful outcome in 27 of 30 of women (90%) whose condition had failed to respond to boric acid and azole therapy. Local side effects were uncommon with both regimens.CONCLUSIONS: Topical boric acid and flucytosine are useful additions to therapy for women with azole-refractory C glabrata vaginitis.
