Thyroid carcinoma and radiation. A Chicago endemic.
Thyroid carcinoma and radiation. A Chicago endemic.
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甲状腺癌和放射。
DOI：
10.1001/jama.1973.03220320021007
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发表时间：
1973
期刊：
影响因子：
--
通讯作者：
E. Paloyan
中科院分区：
文献类型：
--
作者：
L. Degroot;E. Paloyan
与辐射有关的甲状腺癌继续以惊人的频率发生。在过去四年中发现的50例甲状腺癌患者中，有20例接受过颈部X线治疗。这些患者在X射线照射后平均20年发生肿瘤，几乎所有患者的年龄都在35岁以下。临床表现与未暴露的癌症患者相似，但肿瘤侵袭性较低，从未分化。X光组的一名患者死于该病。我们的患者中有三分之二有已知的X射线暴露史，并显示临床甲状腺异常，患有癌症。所有在儿童或青少年时期接受过大量X射线照射的患者都应检查甲状腺异常，这些异常可能在照射后20年或更长时间内发生。
Radiation-associated thyroid carcinomas continue to occur with alarming frequency. Among 50 patients with thyroid carcinoma seen over the past four years, 20 had received prior neck x-ray treatment. These patients developed tumors an average of 20 years after x-ray exposure, and were nearly all under 35 years of age. Clinical findings were similar to those of the nonexposed carcinoma patients, but the tumors were less invasive and never undifferentiated. One patient in the x-ray group succumbed to the illness. Two thirds of our patients who have a history of known x-ray exposure and who showed clinical thyroid abnormalities had cancer. All patients who received significant x-ray exposure during childhood or adolescence should be examined for thyroid abnormalities, which may develop two or more decades after exposure.