Modulation of the neural control of the clasp reflex in male Xenopus laevis by androgens: a multidisciplinary study.
Modulation of the neural control of the clasp reflex in male Xenopus laevis by androgens: a multidisciplinary study.
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雄激素对雄性爪蟾扣反射神经控制的调节：一项多学科研究。
DOI：
10.1073/pnas.78.9.5876
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发表时间：
1981
影响因子：
11.1
通讯作者：
Krieger,NR
中科院分区：
文献类型：
--
作者：
Erulkar,SD;Kelley,DB;Jurman,ME;Zemlan,FP;Schneider,GT;Krieger,NR
应用解剖学、电生理学和生物化学等技术，研究了雄性非洲爪哇扣带反射的神经控制。去势雄性大鼠脊髓节段2的神经元在注射[~3H]-双氢睾酮后积聚LABEL；这些神经元分布在胸骨和腕屈肌的运动神经元池的吻部。体外记录的去势雄性非洲爪鼠的脊髓标本中，从神经到胸腓肌的记录显示，在浴液中加入双氢睾酮后，对成对的背根刺激的激活增加。这种增加可以通过事先给药放线菌亚胺来阻止。还原酶睾酮5α-还原酶存在并选择性地分布在雄性非洲爪哇的脊髓中。据推测，雄激素可能会改变神经元的活动模式，导致“卡环”肌肉，从而影响这些肌肉中的肌球蛋白类型。
The neural control of the clasp reflex in male Xenopus laevis has been studied by using anatomical, electrophysiological, and biochemical techniques. Neurons in spinal segment 2 of castrated males accumulate label after injection of [3H]-dihydrotestosterone; these neurons are distributed within the rostral portions of the motoneuronal pools of the sternoradialis and flexor carpi radialis muscles. In vitro recordings from the nerve to the sternoradialis muscle in the isolated spinal cord preparation from castrated male Xenopus showed increased activation to paired dorsal root stimulation after addition of dihydrotestosterone to the bath. This increase could be prevented by prior administration of cycloheximide. The reducing enzyme testosterone 5 alpha-reductase is present and is selectively distributed in male Xenopus spinal cord. It is speculated that the androgens may alter patterns of neuronal activity leading to the "clasp" muscles and thereby influence myosin types within these muscles.