Effect of glucose-insulin-potassium infusion on thallium myocardial clearance.
Effect of glucose-insulin-potassium infusion on thallium myocardial clearance.
复制标题
葡萄糖-胰岛素-钾输注对铊心肌清除率的影响。
DOI：
10.1161/01.cir.68.1.203
复制
发表时间：
1983
期刊：
影响因子：
37.8
通讯作者：
Pohost,GM
中科院分区：
文献类型：
--
作者：
Wilson,RA;Okada,RD;Strauss,HW;Pohost,GM
影响201Tl心肌清除率的因素尚未明确。这项研究确定了静脉输注葡萄糖-胰岛素-钾(GIK)对有和没有初始201Tl负荷的心肌净201Tl清除率的影响。麻醉开胸犬冠状动脉左前降支结扎5min，静脉注射201Tl，5min后解除结扎。201Tl注射后30分钟，静脉滴注30毫升GIK(9只)或生理盐水(5只)。用放置在心肌上的微型碲化镉探测器监测201Tl从前壁(无201Tl初始负荷)和后壁(201Tl初始负荷)的清除率。通过线性回归分析从连续的1min计数中计算净心肌清除率。与生理盐水输注相比，GIK在有无初始负荷的情况下增加了两个心肌区201Tl的净清除量。GIK输注引起的最显著变化是在没有201Tl负荷的心肌区域；201Tl活性的净增加(72+/-42cpm/30min)转化为净损失(-594+/-228cpm/30min)。输注生理盐水后，201Tl清除量无明显变化。心率、主动脉和左房压力、声波测微仪测量的跨壁心肌壁厚度、微球测量的心肌血流量以及血糖和钾浓度在GIK或生理盐水输注期间没有显著变化。因此，无论有无初始201Tl负荷，GIK输注似乎都能增加201Tl从心肌区的净清除量。
Factors influencing the rate of 201Tl clearance from the myocardium have not been clearly defined. This study determined the effect of an intravenous infusion of glucose-insulin-potassium (GIK) on the net 201Tl clearance rates from myocardium with and without initial 201Tl loading. Anesthetized open-chest dogs underwent 5 min of left anterior descending coronary artery occlusion and intravenous 201Tl was injected and the occlusion released 5 min later. Thirty minutes after 201Tl injection, 30 ml of either GIK (nine dogs) or saline (five dogs) was infused intravenously. The clearance rates of 201Tl from the anterior wall (without initial 201Tl loading) and from the posterior wall (with initial 201Tl loading) were monitored with miniaturized cadmium telluride detectors placed on the myocardium. Calculation of net myocardial clearance rates was performed by linear regression analysis from serial 1 min counts. Compared with saline infusion, GIK increased the net clearance of 201Tl from both myocardial regions with and without initial loading. The most marked change induced by GIK infusion was in the myocardial region without initial 201Tl loading; a net increase in 201Tl activity (72 +/- 42 cpm/30 min) was converted into a net loss (-594 +/- 228 cpm/30 min). There was no significant change in 201Tl clearance after the saline infusion. Heart rate, aortic and left atrial pressure, sonomicrometer-measured transmural myocardial wall thickness, microsphere-determined myocardial blood flow, and blood glucose and potassium concentrations did not change significantly during GIK or saline infusions. Thus, GIK infusion appears to increase net 201Tl clearance from myocardial zones with and without initial 201Tl loading.