NONUNIFORM CONDUCTION TIME IN THE OLIVOCEREBELLAR PATHWAY IN THE ANESTHETIZED CAT
NONUNIFORM CONDUCTION TIME IN THE OLIVOCEREBELLAR PATHWAY IN THE ANESTHETIZED CAT
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DOI：
10.1113/jphysiol.1995.sp020851
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发表时间：
1995-08-01
影响因子：
5.5
通讯作者：
EDGLEY, SA
中科院分区：
文献类型：
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作者：
AGGELOPOULOS, NC;DUKE, C;EDGLEY, SA
1.最近已经证明，在大鼠小脑攀爬纤维传入的传导速度调谐根据纤维长度，使它们的起源在下橄榄和它们的目标皮质浦肯野细胞之间的传导时间是恒定的。在这里，我们已经研究了猫的情况，其中单个攀爬纤维相当长。电刺激位于小脑蚓部不同深度的浦肯野细胞（a区和B区）的橄榄小脑纤维，诱发其起源的复合棘波反应，并在细胞外或细胞内记录.直接诱发复合锋电位的起始潜伏期为2.6 ~ 6.9 ms，在每个电极的穿透过程中，复合锋电位潜伏期的一致趋势是：表层细胞（橄榄小脑纤维长度最长处）的复合锋电位潜伏期较长，深层细胞（橄榄小脑纤维长度较短处）的复合锋电位潜伏期较短.线性回归分析表明，猫橄榄小脑纤维的传导时间不是固定的，而是随传导距离呈线性变化。我们的发现与橄榄小脑纤维的传导速度约为6.6 m s（-1）是一致的。
1. It has recently been demonstrated that conduction velocities of cerebellar climbing fibre afferents in the rat are tuned according to fibre length such that conduction time between their origin in the inferior olive and their target cortical Purkinje cells is constant. Here we have examined the situation in the cat, where individual climbing fibres are substantially longer. Complex spike responses of Purkinje cells located at various depths in the vermis (zones a and b) were evoked by electrical stimulation of olivocerebellar fibres dose to their origin and were recorded either extra- or intracellularly.2. The onset latencies of directly evoked complex spikes ranged from 2.6 to 6.9 ms. A consistent trend in each electrode penetration was that the complex spike latencies were longer for the superficially encountered cells (where olivocerebellar fibre length is greatest) and shorter for deeper cells (where olivocerebellar fibre length is shorter).3. Linear regression analysis suggests that conduction time in olivocerebellar fibres in the cat is not fixed but varies linearly with conduction distance. Our findings would be consistent with a conduction conduction velocity in olivocerebellar fibres of about 6.6 m s(-1).