Engineering Static and Dynamic Control of Synthetic Pathways
Engineering Static and Dynamic Control of Synthetic Pathways
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DOI：
10.1016/j.cell.2009.12.029
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发表时间：
2010-01-08
期刊：
影响因子：
64.5
通讯作者：
Keasling, Jay D.
中科院分区：
文献类型：
--
作者：
Holtz, William J.;Keasling, Jay D.
使所需小分子的产生最大化是代谢工程的主要目标之一。合成生物学的新生领域的最新进展增加了在恒定条件下生长的工程细胞中小分子生产的可预测性。下一个前沿是创造适应不断变化的环境的合成途径。
Maximizing the production of a desired small molecule is one of the primary goals in metabolic engineering. Recent advances in the nascent field of synthetic biology have increased the predictability of small-molecule production in engineered cells growing under constant conditions. The next frontier is to create synthetic pathways that adapt to changing environments.