Reduced E-cadherin expression is an indicator of unfavourable prognosis in oral squamous cell carcinoma
Reduced E-cadherin expression is an indicator of unfavourable prognosis in oral squamous cell carcinoma
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DOI：
10.1016/j.oraloncology.2005.07.010
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发表时间：
2006-02-01
期刊：
影响因子：
4.8
通讯作者：
García-García, A
中科院分区：
文献类型：
--
作者：
Diniz-Freitas, M;García-Caballero, T;García-García, A
目的是评估E-钙粘蛋白在口腔鳞状细胞癌中的表达，及其与肿瘤组织学、临床病程和生存率的可能关系。应用免疫组织化学方法检测47例口腔鳞癌组织中E-钙粘蛋白的表达。进行统计分析，以确定可能的关联与肿瘤的临床组织学特征和临床过程和生存。弱或缺乏E-钙粘蛋白表达与更具侵袭性的组织学模式和颈部淋巴结转移有关。单因素和多因素分析表明，E-cadherin表达弱或检测不到是无病期和生存期较短的指标。口腔鳞状细胞癌中E-cadherin表达减少与肿瘤更具侵袭性和预后不良相关。(c)2005爱思唯尔有限公司保留所有权利。
The aim was to evaluate E-cadherin expression in oral squamous cell carcinoma, and its possible relationships with tumour histology and with clinical course and survival. Surgical biopsies from 47 cases of oral squamous cell carcinoma were analysed for expression of E-cadherin using immunohistochemistry. Statistical analyses were performed to identify possible associations with tumour clinic-histological features and with clinical course and survival. Weak or absent E-cadherin expression was associated with a more invasive histological pattern and with metastasis to the cervical lymph nodes. Uni- and multivariate analyses indicated that weak or undetectable E-cadherin expression is an indicator of shorter disease-free period and shorter survival time. Reduced E-cadherin expression in oral squamous cell carcinoma is associated with more aggressive tumour behaviour and worse prognosis. (c) 2005 Elsevier Ltd. All rights reserved.