DIETARY-REGULATION OF GLUCOSE-TRANSPORTER GENE-EXPRESSION - TISSUE-SPECIFIC EFFECTS IN ADIPOSE-CELLS AND MUSCLE
DIETARY-REGULATION OF GLUCOSE-TRANSPORTER GENE-EXPRESSION - TISSUE-SPECIFIC EFFECTS IN ADIPOSE-CELLS AND MUSCLE
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DOI：
10.1093/jn/124.suppl_8.1289s
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发表时间：
1994-08-01
影响因子：
4.2
通讯作者：
KAHN, BB
中科院分区：
文献类型：
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作者：
KAHN, BB
快速刺激葡萄糖转运到典型的胰岛素反应组织，肌肉和脂肪细胞，对于维持进食状态下的葡萄糖稳态至关重要。饮食中常量营养素的含量和组成通过改变葡萄糖转运基因（GLUT1和GLUT4）的表达和基因产物的功能活性，强烈影响葡萄糖向这些组织的转运。饮食对GLUT1和GLUT4的调节是组织特异性的。与高脂肪喂养相比，脂肪细胞中转运蛋白表达的改变要大得多。在未喂食状态下，脂肪细胞中的葡萄糖转运蛋白基因表达深度下调，而骨骼肌中相同转运蛋白基因的表达增加，因此，葡萄糖转运蛋白表达和功能的组织特异性调节似乎是在营养可用性改变时维持足够细胞营养的适应性反应的一部分。
The rapid stimulation of glucose transport into the classic insulin responsive tissues, muscle and adipose cells, is crucial for maintenance of glucose homeostasis in the fed state. Macronutrient content and composition of the diet strongly influence glucose transport into these tissues by altering both the expression of the glucose transporter genes (GLUT1 and GLUT4) and the functional activity of the gene products. Dietary regulation of GLUT1 and GLUT4 is tissue specific. With high fat feeding alterations in transporter expression is much greater in adipose cells than in skeletal muscle. In the unfed state there is a profound down regulation of glucose transporter gene expression in adipose cells while expression of the same transporter genes is increased in skeletal muscle, Thus, tissue specific regulation of glucose transporter expression and function appears to be part of the adaptive response to maintain adequate cellular nutrition in times of altered nutrient availability.