Asbestos-related pleural plaques and lung function.
Asbestos-related pleural plaques and lung function.
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石棉相关的胸膜斑块和肺功能。
DOI：
10.1002/ajim.4700140604
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发表时间：
1988
影响因子：
3.5
通讯作者：
Sprince,NL
中科院分区：
文献类型：
--
作者：
Oliver,LC;Eisen,EA;Greene,R;Sprince,NL
本研究探讨了一组职业暴露于石棉的工人中石棉相关胸膜斑块与肺功能之间的关系。获得了383名铁路工人的暴露、吸烟和呼吸史、胸片、流量环和单次呼吸DLCO。使用基于ILO‐1980分类系统的评分来量化斑块样增厚的程度。为了消除潜在的混杂因素，我们从最终分析中排除了弥漫性胸膜增厚（n = 10）或胸部X线片上归类为灌注0/1或更大的小不规则阴影（n = 6）的受试者。22.6%的患者可见明确的胸膜斑。有和无斑块组的单次呼吸DLCO相似（p = 0.0550）。FVC下降和肺限制的发生与明确斑块的存在（分别为p = 0.0306和0.0431）和定量胸膜评分（p = 0.0135和0.0126）相关，控制石棉暴露和吸烟的持续时间。趋势检验显示胸膜斑块的诊断确定性水平（无、可疑、明确）与这些肺功能指标之间存在相关性（p < 0.02）。我们的研究结果揭示了石棉相关性胸膜斑块与肺功能下降（通过FVC和肺限制标准测量）之间的相关性。
The present study examines the association between asbestos‐related pleural plaques and lung function in a group of workers with occupational exposure to asbestos. Exposure, smoking, and respiratory histories, chest radiographs, flow‐volume loops, and single breath DLCOs were obtained on 383 railroad workers. A score based on the ILO‐1980 classification system was used to quantify the extent of plaquelike thickening. In order to eliminate potential confounders, we excluded from final analysis subjects with diffuse pleural thickening (n = 10) or small irregular opacities classified as profusion 0/1 or greater (n = 6) on chest radiograph. Definite pleural plaques were observed in 22.6%. The single breath DLCO was similar in the groups with and without plaques (p = 0.0550). Decrement in FVC and the occurrence of pulmonary restriction were associated with the presence of definite plaques (p = 0.0306 and 0.0431, respectively) and with quantitative pleural score (p = 0.0135 and 0.0126), controlling for duration of asbestos exposure and smoking. A test for trend revealed an association between level of diagnostic certainty (none, suspect, definite) for pleural plaques and these measures of lung function (p < 0.02). Our findings reveal an association between asbestos‐related pleural plaques and decrement in lung function as measured by FVC and criteria for pulmonary restriction.