Repetitive head impact exposure and later-life plasma total tau in former National Football League players.
Repetitive head impact exposure and later-life plasma total tau in former National Football League players.
复制标题
DOI：
10.1016/j.dadm.2016.11.003
复制
发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Stern RA
中科院分区：
文献类型：
--
作者：
Alosco ML;Tripodis Y;Jarnagin J;Baugh CM;Martin B;Chaisson CE;Estochen N;Song L;Cantu RC;Jeromin A;Stern RA
血液总tau蛋白分析(t-tau)可能是慢性创伤性脑病(CTE)的实用筛查生物标志物，CTE是一种与重复头部撞击(RHI)暴露相关的神经退行性脑病。我们检测了有症状的前国家橄榄球联盟(NFL)球员和对照组的血浆t-tau，以及RHI暴露与晚年血浆t-tau的关系。96名前NFL球员(年龄40-69岁)和25名同龄对照组进行了抽血，以测定血浆t-tau水平。累积头部撞击指数(CHII)量化了RHI暴露。受试者完成临床功能测量。Chii越高，前NFL球员的血浆t-tau就越高(P=4.0137)。血浆t-tau水平没有组间差异，但≥浓度3.56pg/ml是前国家橄榄球联盟球员的100%特异性。血浆t-tau不能预测临床功能。更大的RHI暴露预示着更高的晚年血浆t-tau浓度，进一步研究血浆t-tau作为CTE候选筛查生物标志物是有必要的。
Blood protein analysis of total tau (t-tau) may be a practical screening biomarker for chronic traumatic encephalopathy (CTE), a neurodegenerative tauopathy associated with repetitive head impact (RHI) exposure. We examined plasma t-tau in symptomatic former National Football League (NFL) players compared with controls and the relationship between RHI exposure and later-life plasma t-tau. Ninety-six former NFL players (age 40–69) and 25 same-age controls underwent blood draw to determine plasma t-tau levels. The cumulative head impact index (CHII) quantified RHI exposure. Subjects completed measures of clinical function. A higher CHII predicted greater plasma t-tau in the former NFL players (P = .0137). No group differences in plasma t-tau emerged, but a concentration ≥3.56 pg/mL was 100% specific to former NFL players. Plasma t-tau did not predict clinical function. Greater RHI exposure predicted higher later-life plasma t-tau concentrations, and further study on plasma t-tau as a candidate screening biomarker for CTE is warranted.