Distinct Diagnostic and Prognostic Values of Minichromosome Maintenance Gene Expression in Patients with Hepatocellular Carcinoma.
Distinct Diagnostic and Prognostic Values of Minichromosome Maintenance Gene Expression in Patients with Hepatocellular Carcinoma.
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DOI：
10.7150/jca.25221
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发表时间：
2018
影响因子：
3.9
通讯作者：
Peng T
中科院分区：
文献类型：
--
作者：
Liao X;Liu X;Yang C;Wang X;Yu T;Han C;Huang K;Zhu G;Su H;Qin W;Huang R;Yu L;Deng J;Zeng X;Ye X;Peng T
背景资料：本研究的目的是确定微小染色体维持（MCM）基因表达在肝细胞癌（HCC）患者中的诊断和预后价值。方法：应用生物信息学分析方法研究MCM基因的生物学功能。MCM基因的诊断和预后价值进行了研究，使用的数据来自GSE 14520和癌症基因组图谱（TCGA）数据库的HCC患者。结果如下：对MCM基因的生物信息学分析证实，MCM 2 -7基因在DNA复制和细胞周期中显著富集，并且相互共表达。这些基因也在GSE 14520和TCGA组的HCC肿瘤组织中共表达。我们还观察到MCM 2 -7基因在肿瘤组织中的表达增加，并且MCM 2 -7的诊断受试者操作特征分析表明这些基因可以作为HCC的敏感诊断标志物。GSE 14520队列的生存分析表明，MCM 2、MCM 4、MCM 5和MCM 6的表达与B型肝炎病毒相关的HCC总生存率（OS）显著相关。然而，没有一个MCM基因与GSE 14520队列的无复发生存率相关。结论：MCM 2 -7基因可能是HCC患者潜在的诊断标志物。其中，MCM 2和MCM 6可能作为HCC的潜在预后生物标志物。
Background: The aim of the present study was to identify diagnostic and prognostic values of minichromosome maintenance (MCM) gene expression in patients with hepatocellular carcinoma (HCC). Methods: The biological function of the MCM genes were investigated by bioinformatics analysis. The diagnostic and prognostic values of the MCM genes were investigated by using the data of HCC patients from the GSE14520 and The Cancer Genome Atlas (TCGA) databases. Results: Bioinformatics analysis of the MCM genes substantiated that MCM2-7 genes were significantly enriched in DNA replication and cell cycle, and co-expressed with each other. These genes also co-expressed in HCC tumor tissue in both the GSE14520 and TCGA cohort. We also observed that the expression of the MCM2-7 genes was increased in tumor tissue, and diagnostic receiver operating characteristic analysis of MCM2-7 indicated that these genes could serve as sensitive diagnostic markers in HCC. Survival analysis in the GSE14520 cohort suggested that expression of MCM2, MCM4, MCM5, and MCM6 were significantly associated with hepatitis B virus-related HCC overall survival (OS). However, none of the MCM genes were associated with recurrence-free survival in the GSE14520 cohort. The validation cohort of TCGA suggested that the expression of MCM2, MCM6, and MCM7 were significantly correlated with HCC OS. Conclusion: Our study indicated that MCM2-7 genes may be potential diagnostic biomarkers in patients with HCC. Among them, MCM2 and MCM6 may serve as potential prognostic biomarkers for HCC.
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影响因子：
8.8
作者：
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影响因子：
4.2
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影响因子：
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DOI：
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发表时间：
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影响因子：
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作者：
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影响因子：
5.6
作者：
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