DUFs: families in search of function
DUFs: families in search of function
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DOI：
10.1107/s1744309110001685
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发表时间：
2010-10-01
影响因子：
0.9
通讯作者：
Finn, Robert D.
中科院分区：
文献类型：
--
作者：
Bateman, Alex;Coggill, Penny;Finn, Robert D.
未知功能域（DUFs）是在Pfam数据库中发现的一大组未表征的蛋白质家族。本文综述了生物数据库中功能未表征家族的规模和增长，并对发现其功能的前景进行了展望。特别是，结构基因组学在鉴定潜在功能方面的重要作用被评估。
Domains of unknown function (DUFs) are a large set of uncharacterized protein families that are found in the Pfam database. Here, the scale and growth of functionally uncharacterized families in biological databases are surveyed and the prospects for discovering their function are examined. In particular, the important role that structural genomics can play in identifying potential function is evaluated.