Frequency of Val1016Ile mutation in the voltage-gated sodium channel gene of Aedes aegypti Brazilian populations
Frequency of Val1016Ile mutation in the voltage-gated sodium channel gene of Aedes aegypti Brazilian populations
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DOI：
10.1111/j.1365-3156.2009.02378.x
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发表时间：
2009-11-01
影响因子：
3.3
通讯作者：
Valle, Denise
中科院分区：
文献类型：
--
作者：
Martins, Ademir Jesus;Pereira Lima, Jose Bento;Valle, Denise
昆虫对拟除虫菊酯类杀虫剂产生抗性的主要机制之一是影响其靶位电压门控钠通道（Na-v）。在埃及伊蚊中，AaNa(v)基因的Val1016Ile替换与若干拉丁美洲国家的耐药性有关。对来自巴西7个地区的易感和耐药蚊子进行基因分型，在5个种群中检测到1016Ile突变，在所有病例中耐药样本中这种替换的频率更高。此外，对另外9个大田群体的分析显示，其中5个也出现了1016Ile突变。我们的数据表明，这种替代方法最近在巴西传播并涉及到拟除虫菊酯耐药性。
One of the major insect pyrethroid resistance mechanisms affects its target site, the voltage-gated sodium channel (Na-v). In Aedes aegypti, the Val1016Ile substitution of the AaNa(v) gene is associated to resistance in several Latin American countries. Genotyping of susceptible and resistant mosquitoes from seven Brazilian localities detected the 1016Ile mutation in five populations with a higher frequency of this substitution in resistant specimens in all cases. Furthermore, analysis of nine additional field populations revealed that five also presented the 1016Ile mutation. Our data suggest a recent dissemination and involvement of this substitution with pyrethroid resistance in Brazil.