Family History as an Important Factor for Stratifying Participants in Genetic Studies of Major Depression.
Family History as an Important Factor for Stratifying Participants in Genetic Studies of Major Depression.
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DOI：
10.2478/bjmg-2018-0010
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发表时间：
2018-06
期刊：
影响因子：
--
通讯作者：
Peterlin B
中科院分区：
文献类型：
--
作者：
Zalar B;Blatnik A;Maver A;Klemenc-Ketiš Z;Peterlin B
据估计，抑郁症影响着全世界3.5亿人。在17个国家进行的世界心理健康调查发现，平均每20人中就有一人报告在前一年有过抑郁症发作。尽管过去的研究表明抑郁症具有一定的遗传性，但迄今为止，对其所谓的缺失遗传性的研究并不成功。识别易患抑郁症的常见遗传变异的困难可能是由于检测对遗传风险的小影响所需的大样本量和重度抑郁症（MDD）的异质性。我们研究的目的是确定MDD患者的抑郁症家族史与研究充分的SLC6A4、COMT和PCLO基因中存在推定风险变体之间是否存在联系。我们分析了133例MDD患者（30.0%有MDD阳性家族史，70.0%为散发病例），并将其与279例健康对照进行了比较。当将所有抑郁症患者与对照组进行比较时，没有检测到基因型和等位基因分布的显著差异。根据家族史对患者进行分层后，PCLO rs2522833 C等位基因在阳性家族史患者中明显不常见（p = 0.001），表明家族性和散发性病例之间MDD的遗传结构可能存在差异，并且常见遗传风险变体在家族性病例中MDD发展中的作用不太重要。
Depression is estimated to affect 350 million people worldwide. The World Mental Health Survey conducted in 17 countries found that, on average, about one in 20 people reported having an episode of depression in the previous year. Although depression has been shown to be moderately heritable by studies conducted in the past, the search for its so-called missing heritability has so far been unsuccessful. The difficulty in identifying common genetic variants predisposing to depression could be due to large sample sizes needed to detect small effects on genetic risk and the heterogeneous nature of major depressive disorder (MDD). The aim of our study was to determine whether there was a connection between a family history of depression in MDD patients and the presence of putative risk variants in the well-studied SLC6A4, COMT and PCLO genes. We analyzed 133 patients with MDD (30.0% with a positive family history for MDD and 70.0% sporadic cases) and compared them to 279 healthy controls. When comparing all the depressed patients to controls, no significant differences in genotype and allele distributions were detected. After stratifying patients according to their family history, the PCLO rs2522833 C allele was shown to be significantly less common in patients with a positive family history (p = 0.001), indicating a possible difference in the genetic structure of MDD between familial and sporadic cases and a less important role of the common genetic risk variants for the development of MDD in familial cases.
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影响因子：
11
作者：
Bosker, F. J.;Hartman, C. A.;Nolen, W. A.
通讯作者：
Nolen, W. A.
影响因子：
30.8
作者：
Lee, S. Hong;Ripke, Stephan;Neale, Benjamin M.;Faraone, Stephen V.;Purcell, Shaun M.;Perlis, Roy H.;Mowry, Bryan J.;Thapar, Anita;Goddard, Michael E.;Witte, John S.;Absher, Devin;Agartz, Ingrid;Akil, Huda;Amin, Farooq;Andreassen, Ole A.;Anjorin, Adebayo;Anney, Richard;Anttila, Verneri;Arking, Dan E.;Asherson, Philip;Azevedo, Maria H.;Backlund, Lena;Badner, Judith A.;Bailey, Anthony J.;Banaschewski, Tobias;Barchas, Jack D.;Barnes, Michael R.;Barrett, Thomas B.;Bass, Nicholas;Battaglia, Agatino;Bauer, Michael;Bayes, Monica;Bellivier, Frank;Bergen, Sarah E.;Berrettini, Wade;Betancur, Catalina;Bettecken, Thomas;Biederman, Joseph;Binder, Elisabeth B.;Black, Donald W.;Blackwood, Douglas H. 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通讯作者：
Wray, Naomi R.
影响因子：
3.5
作者：
Hek, Karin;Mulder, Cornelis L.;Tiemeier, Henning
通讯作者：
Tiemeier, Henning
影响因子：
64.8
作者：
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通讯作者：
Daar, Abdallah S.
影响因子：
11
作者：
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通讯作者：
Viktorin, Alexander