Combined Signature of the Fecal Microbiome and Metabolome in Patients with Gout.
Combined Signature of the Fecal Microbiome and Metabolome in Patients with Gout.
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DOI：
10.3389/fmicb.2017.00268
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发表时间：
2017
影响因子：
5.2
通讯作者：
Wen C
中科院分区：
文献类型：
--
作者：
Shao T;Shao L;Li H;Xie Z;He Z;Wen C
本研究采用微生物组和代谢组分析来探索痛风患者的粪便特征。通过1H NMR光谱和Illumina Miseq测序分析来自52名男性个体（26名健康对照和26名痛风患者）的粪便样品。微生物群特征显示条件致病菌如拟杆菌、紫单胞菌科、红球菌、丹毒梭菌和厌氧菌科的表达上调。代谢物组学特征是一些改变的代谢物，可能涉及尿酸排泄、嘌呤代谢和炎症反应。同时，差异代谢物和微生物类群之间的相关性表明它们可能是痛风的联合特征。这项研究表明，粪便微生物组和代谢组的联合分析可以有效地表征疾病。
This study employed microbiome and metabolome analysis to explore the fecal signatures of gout patients. Fecal samples from 52 male individuals (26 healthy controls and 26 gout patients) were analyzed by 1H NMR spectroscopy and Illumina Miseq sequencing. The signatures of microbiome showed being up-regulation of opportunistic pathogens, such as Bacteroides, Porphyromonadaceae Rhodococcus, Erysipelatoclostridium and Anaerolineaceae. The signatures of metabolome were some altered metabolites which may involve uric acid excretion, purine metabolism, and inflammatory responses. Meanwhile, the correlation between discrepant metabolites and microbial taxa indicated that they could be the combined signatures of gout. This study suggests that the combined analysis of the fecal microbiome and metabolome may effectively characterize diseases.