Viral Interplay with the Host Sumoylation System
Viral Interplay with the Host Sumoylation System
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DOI：
10.1007/978-90-481-2649-1_18
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发表时间：
2009-01-01
期刊：
影响因子：
--
通讯作者：
Wilson, Van G.
中科院分区：
文献类型：
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作者：
Deyrieux, Adeline F.;Wilson, Van G.
病毒有复杂的方法来调节细胞转录，以创造一个促进病毒生存和繁殖的细胞环境。这包括增强病毒大分子合成和防止抗病毒反应，如细胞凋亡和细胞周期阻滞。病毒通过多种机制介导其对宿主细胞的影响，这包括针对各种细胞翻译后修饰系统，包括聚合化。sumoylation对细胞过程的广泛影响，如转录调节、细胞凋亡和细胞周期控制，使其成为病毒失调的一个有吸引力的靶点。迄今为止，来自RNA和DNA病毒家族的蛋白质已被证明可以通过SUMO偶联进行修饰，这种修饰似乎对病毒蛋白质功能至关重要。更有趣的是，一些DNA病毒家族的成员，包括乳头瘤病毒、腺病毒和疱疹病毒，已经被证明可以调节聚合化。本章将重点讨论这些病毒破坏聚合化的机制以及这种破坏对病毒感染和疾病的影响。
Viruses have elaborate means to regulate cellular transcription in order to create a cellular environment that facilitates viral survival and reproduction. This includes enhancing viral macromolecular synthesis and preventing antiviral responses such as apoptosis and cell cycle arrest. There are numerous mechanisms by which viruses mediate their effects on the host cell, and this includes targeting various cellular post-translational modification systems, including sumoylation. The wide-ranging impact of sumoylation on cellular processes such as transcriptional regulation, apoptosis, and cell cycle control makes it an attractive target for viral dysregulation. To date, proteins from both RNA and DNA virus families have been shown to be modified by SUMO conjugation, and this modification appears critical for viral protein function. More interestingly, several members of the DNA virus families have been shown to modulate sumoylation, including papillomaviruses, adenoviruses, and herpesviruses. This chapter will focus on mechanisms by which these viruses disrupt sumoylation and the implications of this disruption for viral infection and disease.