Association of osteoporosis and bone medication with the periodontal condition in elderly women
Association of osteoporosis and bone medication with the periodontal condition in elderly women
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DOI：
10.1007/s00198-015-3437-y
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发表时间：
2016-05-01
影响因子：
4
通讯作者：
Leo, A. T. T.
中科院分区：
文献类型：
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作者：
Penoni, D. C.;Torres, S. R.;Leo, A. T. T.
本研究探讨骨质疏松症及其治疗是否会影响老年妇女的牙周状况。研究结果强调，骨质疏松症的女性比骨密度正常的女性有更高的机会出现严重的牙周炎，特别是那些没有接受骨质疏松症治疗的女性。本研究调查骨质疏松是否会增加老年妇女慢性牙周炎的频率和严重程度，并评估维生素D和骨质疏松治疗对牙周状况的影响。在这项横断面研究中，从1266名受试者中选择老年妇女，使用双能x线骨密度仪评估腰椎和股骨近端骨密度（BMD）。记录社会人口学、临床特征和完整的牙周检查。化学发光法测定血清25-羟基维生素D水平。选择骨密度正常的老年妇女48例，骨质疏松症86例。骨质疏松症女性出现临床附着水平为千分之一毫米（p = 0.003）、牙龈退缩为千分之一毫米（p = 0.002）的频率高于骨密度正常女性，出现严重牙周炎的可能性是正常女性的两倍多（优势比(OR) = 2.49, 95% CI[1.14 ~ 5.43]）。未接受治疗的骨质疏松症女性出现严重牙周炎的几率（OR = 3.16, 95% CI[1.28 ~ 7.82]）高于使用双膦酸盐的女性（OR = 2.04, 95% CI[0.85 ~ 4.89]）。在维生素D水平较低的参与者中，骨质疏松症患者出现严重牙周炎的几率高于骨密度正常者（p = 0.027），但调整后维生素D水平与骨质疏松症之间的相关性无统计学意义（p = 0.198）。患有骨质疏松症的老年妇女有更大的机会出现牙周炎，其严重程度高于骨密度正常的妇女。骨质疏松症治疗可保护牙周炎。
This study investigated whether osteoporosis and its treatment may affect periodontal condition in elderly women. The findings highlighted that women with osteoporosis had a higher chance to present severe periodontitis than women with normal bone mineral density (BMD), particularly those who were not treated for osteoporosis.This study investigated whether osteoporosis increases the frequency and severity of chronic periodontitis in elderly women and evaluated the influence of vitamin D and osteoporosis treatment in the periodontal condition.In this cross-sectional study, elderly women were selected among 1266 subjects evaluated for lumbar spine and proximal femur bone mineral density (BMD) using dual energy X-ray absorptiometry. Sociodemographic, clinical characteristics, and complete periodontal examination were recorded. Serum 25-hydroxyvitamin D levels were measured by chemiluminescence.Forty-eight elderly women with normal BMD and 86 with osteoporosis were selected. Women with osteoporosis presented higher frequency of sites with clinical attachment level a parts per thousand yen6 mm (p = 0.003) and gingival recession a parts per thousand yen3 mm (p = 0.002) than those with normal BMD and were more than twice as likely to present severe periodontitis (odds ratio (OR) = 2.49, 95 % CI [1.14 to 5.43]). Osteoporotic women who were not treated for the condition had more chance to present severe periodontitis (OR = 3.16, 95 % CI [1.28 to 7.82]) than those who did use bisphosphonates (OR = 2.04, 95 % CI [0.85 to 4.89]). Among the participants who presented low levels of vitamin D, those with osteoporosis exhibited a higher chance to present severe periodontitis than those with normal BMD (p = 0.027), but the association between vitamin D levels and osteoporosis was not statistically significant after adjustment (p = 0.198).Elderly women with osteoporosis have a greater chance to present periodontitis, with higher severity than those with normal BMD. Osteoporosis treatment provides protection for periodontitis.