Increased Frequency of CD39+ CD56bright Natural Killer Cells in HIV-1 Infection Correlates With Immune Activation and Disease Progression
Increased Frequency of CD39+ CD56bright Natural Killer Cells in HIV-1 Infection Correlates With Immune Activation and Disease Progression
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DOI：
10.1097/qai.0000000000001266
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发表时间：
2017-04-01
影响因子：
3.6
通讯作者：
zur Wiesch, Julian Schulze
中科院分区：
文献类型：
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作者：
Dierks, Patrick;Wroblewski, Raluca;zur Wiesch, Julian Schulze
本文检测了61例HIV-1感染者外周血单个核细胞（PBMC）中自然杀伤（NK）细胞表面胞外核苷酸酶CD_（39）和CD_（73）的表达。在未经治疗的HIV患者中可检测到CD 39（+）CD 56 bright NK细胞频率增加，这与高病毒载量、低CD 4（+）T细胞计数和CD 8（+）T细胞活化有关。此外，NK细胞上的CD 39水平可通过体外刺激NK细胞诱导，与芳烃受体和白细胞介素10表达相关。在这里，我们提供了第一个证据，增加CD 39（+）CD 56 bright NK细胞频率在HIV感染，这可能会对NK细胞功能和HIV发病机制的后果。
The expression pattern of the ectonucleotidases CD39 and CD73 on natural killer (NK) cells was examined in peripheral blood mononuclear cell of 61 HIV-1-infected patients. Increased frequencies of CD39(+) CD56bright NK cells were detectable in untreated HIV patients, which was associated with high viral load, low CD4(+) T-cell count, and CD8(+) T-cell activation. Additionally, levels of CD39 on NK cells were inducible by in vitro stimulation of NK cells, correlating with aryl hydrocarbon receptor and interleukin 10 expression. Here, we provide the first evidence of increased CD39(+) CD56bright NK cell frequencies during HIV infection, which might have consequences for NK cell function and HIV pathogenesis.