Role of Ca 2 (cid:1) /Calmodulin Signaling Pathway on Morphological Development of Candida albicans
Role of Ca 2 (cid:1) /Calmodulin Signaling Pathway on Morphological Development of Candida albicans
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一种人类真菌病原体，白色念珠菌，由于各种外部信号的影响，从酵母菌形态到菌丝体形态都不同。这种形态发生的转变被认为与致病性的发展有关。在这份报告中，我们显示了钙调蛋白抑制剂(TFP和W-7)和腺苷环化酶抑制剂(MDL-12-330A)抑制白色念珠菌的菌丝形成。此外，这些抑制剂还抑制了位于fi-cAMP途径下游的菌丝专一性RAS1 c mRNAs的表达。加入cAMP不能抑制TFP或W-7对菌丝形成的抑制作用，也不影响白念珠菌中cAMP的含量。这些结果表明，钙/钙调蛋白途径参与菌丝的形成，并与RAS1-cAMP途径有关。
A human fungal pathogen, Candida albicans , varies from the yeast form to the hyphal form due to various external signals. This morphogenetic transformation has been implicated in the development of pathogenicity. In this report, we show that calmodulin inhibitors (TFP and W-7) and an adenylatecyclase inhibitor (MDL-12-330A) suppressed the hyphae formation of C. albicans . Furthermore, the expression of hyphae-specific mRNAs located downstream from the RAS1-cAMP pathway was inhibited by these inhibitors. Suppression of hyphae formation by TFP or W-7 was not inhibited by the addition of cAMP, and these inhibitors did not affect the amount of cAMP in C. albicans . These results suggest that the Ca 2 (cid:1) /calmodulin pathway contributes to hyphae formation and is related to the RAS1-cAMP pathway.