THYROID-HORMONES PROMOTE TRANSCRIPTIONAL ACTIVATION OF THE NUCLEAR GENE CODING FOR MITOCHONDRIAL BETA-F(1)-ATPASE IN RAT-LIVER
THYROID-HORMONES PROMOTE TRANSCRIPTIONAL ACTIVATION OF THE NUCLEAR GENE CODING FOR MITOCHONDRIAL BETA-F(1)-ATPASE IN RAT-LIVER
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DOI：
10.1016/0014-5793(93)81459-d
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发表时间：
1993-05-24
期刊：
影响因子：
3.5
通讯作者：
CUEZVA, JM
中科院分区：
文献类型：
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作者：
IZQUIERDO, JM;CUEZVA, JM
甲状腺激素在转录和/或转录后水平上急性调节甲状腺功能减退大鼠新生儿肝脏中线粒体 F1-ATP 酶复合物的 β 催化亚基的基因表达 [(1990) J. Biol.化学。 265、9090-9097]。出生时给予甲状腺功能减退新生大鼠不同剂量的甲状腺激素可促进肝脏 β-F1-ATPase 蛋白和 mRNA 稳态量快速（1 小时）增加。 β-F1-ATPase mRNA 的诱导与使用分离细胞核合成的新生 RNA 链检测到的基因转录升高一致。这些结果表明甲状腺激素诱导甲状腺功能减退大鼠新生儿肝脏中出生后线粒体分化主要是由β-F1-ATP酶基因的转录调节触发的。
Thyroid hormones acutely regulate gene expression of the beta-catalytic subunit of the mitochondrial F1-ATPase complex in the liver of hypothyroid rat neonates at either a transcriptional and/or post-transcriptional level [(1990) J. Biol. Chem. 265, 9090-9097]. Administration at birth of various thyroid hormone doses to hypothyroid newborn rats promote a rapid (1 h) increase in liver steady-state amounts of both beta-F1-ATPase protein and mRNA. Induction of the beta-F1-ATPase mRNA is coincident with an elevation in gene transcription detected using nascent RNA chains synthesized by isolated nuclei. These results suggest that thyroid hormones induction of postnatal mitochondrial differentiation in the liver of hypothyroid rat neonates is mostly triggered by transcriptional regulation of beta-F1-ATPase gene.